Scamp2 MGI Mouse Gene Detail - MGI:1346518 - secretory carrier membrane protein 2

Symbol

Scamp2
Name

secretory carrier membrane protein 2
Synonyms

Sc2

Feature Type

protein coding gene
IDs

MGI:1346518
NCBI Gene: 24044
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:57468226-57496078 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 31.05 cM
Mapping Data

2 experiments

SNPs within 2kb

636 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346518	protein coding gene	Chr9:57468226-57496081 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034870	protein coding gene	Chr9:56777241-56808788 (+)
A/J	MGP_AJ_G0034851	protein coding gene	Chr9:54946671-54975030 (+)
AKR/J	MGP_AKRJ_G0034780	protein coding gene	Chr9:56207062-56235845 (+)
BALB/cJ	MGP_BALBcJ_G0034843	protein coding gene	Chr9:54731232-54759967 (+)
C3H/HeJ	MGP_C3HHeJ_G0034553	protein coding gene	Chr9:56694409-56722861 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035362	protein coding gene	Chr9:58360079-58389463 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032273	protein coding gene	Chr9:54251049-54277875 (+)
CAST/EiJ	MGP_CASTEiJ_G0033874	protein coding gene	Chr9:56782197-56811838 (+)
CBA/J	MGP_CBAJ_G0034524	protein coding gene	Chr9:60396195-60423799 (+)
DBA/2J	MGP_DBA2J_G0034683	protein coding gene	Chr9:54814157-54842266 (+)
FVB/NJ	MGP_FVBNJ_G0034625	protein coding gene	Chr9:54042355-54069888 (+)
LP/J	MGP_LPJ_G0034766	protein coding gene	Chr9:57074735-57102305 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034668	protein coding gene	Chr9:61895471-61926548 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035384	protein coding gene	Chr9:56230062-56259230 (+)
PWK/PhJ	MGP_PWKPhJ_G0033579	protein coding gene	Chr9:54843165-54872082 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033413	protein coding gene	Chr9:56524312-56553032 (+)
WSB/EiJ	MGP_WSBEiJ_G0033987	protein coding gene	Chr9:56162941-56194150 (+)

Human Ortholog

SCAMP2, secretory carrier membrane protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCAMP2, secretory carrier membrane protein 2
Links

HGNC:10564

NCBI Gene ID: 10066

neXtProt AC: NX_O15127

UniProt: O15127
Chr Location

15q24.1; chr15:74843730-74873365 (-) GRCh38

MGI Vertebrate Homology

Scamp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SCAMP2
Gene Tree

Scamp2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scamp2

ZFIN scamp2

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All Sequences

61
RefSeq

4
UniProt

5
CCDS

CCDS23224.1

Ensembl

ENSMUSG00000040188 (Evidence)
NCBI Gene

24044

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040188	Ensembl Gene Model \| MGI Sequence Detail	27853	C57BL/6J	± kb
transcript	ENSMUST00000045791	Ensembl \| MGI Sequence Detail	2340	Not Applicable
polypeptide	ENSMUSP00000038350	Ensembl \| MGI Sequence Detail	329	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014484 secretory carrier-associated membrane protein 2

(term hierarchy)
InterPro Domains

IPR007273 SCAMP

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All nucleic 18

cDNA 18

Microarray probesets 6

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MGI:2143165

Summaries

All 31

Gene Ontology 3

Phenotypes 9
Earliest

J:43149 Singleton DR, et al., Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. J Cell Sci. 1997 Sep;110(Pt 17):2099-107
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Scamp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85314	Chr9:57468217-57468272 (+)	19 bp
Tssr85315	Chr9:57468284-57468295 (+)	64 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24