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Sgcb Gene Detail
Summary
  • Symbol
    Sgcb
  • Name
    sarcoglycan, beta (dystrophin-associated glycoprotein)
  • Synonyms
    beta-SG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346523
    NCBI Gene: 24051
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73790092-73805080 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346523
 protein coding gene Chr5:73790092-73805133 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029628
 protein coding gene Chr5:73646930-73661930 (-)
A/J MGP_AJ_G0029596
 protein coding gene Chr5:70882681-70897685 (-)
AKR/J MGP_AKRJ_G0029544
 protein coding gene Chr5:73186309-73201290 (-)
BALB/cJ MGP_BALBcJ_G0029605
 protein coding gene Chr5:71595120-71610107 (-)
C3H/HeJ MGP_C3HHeJ_G0029328
 protein coding gene Chr5:73583002-73597989 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030059
 protein coding gene Chr5:76681878-76696974 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027299
 protein coding gene Chr5:66561578-66578213 (-)
CAST/EiJ MGP_CASTEiJ_G0028736
 protein coding gene Chr5:72651839-72666855 (-)
CBA/J MGP_CBAJ_G0029297
 protein coding gene Chr5:79193236-79208263 (-)
DBA/2J MGP_DBA2J_G0029442
 protein coding gene Chr5:70965669-70980666 (-)
FVB/NJ MGP_FVBNJ_G0029403
 protein coding gene Chr5:70107750-70122755 (-)
LP/J MGP_LPJ_G0029528
 protein coding gene Chr5:74090893-74105887 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029430
 protein coding gene Chr5:82465887-82480892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030092
 protein coding gene Chr5:72720695-72735693 (-)
PWK/PhJ MGP_PWKPhJ_G0028459
 protein coding gene Chr5:69934183-69949367 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028294
 protein coding gene Chr5:72072103-72089498 (-)
WSB/EiJ MGP_WSBEiJ_G0028816
 protein coding gene Chr5:73023297-73038288 (-)



Homology
more
  • Human Ortholog
    SGCB, sarcoglycan beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGCB, sarcoglycan beta
  • Synonyms
    A3b, LGMD2E, LGMDR4, SGC
  • Links
    NCBI Gene ID: 6443
    neXtProt AC: NX_Q16585
    UniProt: Q16585

  • Chr Location
    4q12; chr4:52020706-52038299 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sgcb mouse models; 2 with human SGCB associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    382 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit muscular dystrophy and cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    36
  • cDNA Data
    53
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24051 NCBI Gene Model | MGI Sequence Detail 14989 C57BL/6J ±  kb
    transcript NM_011890 RefSeq | MGI Sequence Detail 3733 C57BL/6  
    polypeptide P82349 UniProt | EBI | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 55

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2140958, MGI:2140980
    References
    more
    • Summaries
      All 423
      Developmental Gene Expression 4
      Diseases 4
      Gene Ontology 12
      Phenotypes 382
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:358639 Su Y, et al., Brainstem Dbh(+) neurons control allergen-induced airway hyperreactivity. Nature. 2024 Jul;631(8021):601-609
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory