Psmb8 MGI Mouse Gene Detail - MGI:1346527 - proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

Symbol

Psmb8
Name

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
Synonyms

Lmp-7, Lmp7

Feature Type

protein coding gene
IDs

MGI:1346527
NCBI Gene: 16913
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr17:34417169-34420428 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

3 experiments

SNPs within 2kb

5 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346527	protein coding gene	Chr17:34416695-34420428 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023563	protein coding gene	Chr17:34199889-34204392 (+)
A/J	MGP_AJ_G0023525	protein coding gene	Chr17:33039466-33043149 (+)
AKR/J	MGP_AKRJ_G0023490	protein coding gene	Chr17:33424504-33428189 (+)
BALB/cJ	MGP_BALBcJ_G0023529	protein coding gene	Chr17:33197303-33208712 (+)
C3H/HeJ	MGP_C3HHeJ_G0023289	protein coding gene	Chr17:33774281-33778764 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023969	protein coding gene	Chr17:35491856-35498447 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021448	protein coding gene	Chr17:30529604-30533369 (+)
CAST/EiJ	MGP_CASTEiJ_G0022789	protein coding gene	Chr17:33879552-33883226 (+)
CBA/J	MGP_CBAJ_G0023267	protein coding gene	Chr17:36940170-36948877 (+)
DBA/2J	MGP_DBA2J_G0023396	protein coding gene	Chr17:32392836-32396586 (+)
FVB/NJ	MGP_FVBNJ_G0023362	protein coding gene	Chr17:32253011-32257069 (+)
LP/J	MGP_LPJ_G0023473	protein coding gene	Chr17:34469315-34473764 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023385	protein coding gene	Chr17:35923317-35926992 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024012	protein coding gene	Chr17:33765285-33768986 (+)
PWK/PhJ	MGP_PWKPhJ_G0022539	protein coding gene	Chr17:31325643-31331139 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022354	protein coding gene	Chr17:31718751-31722205 (+)
WSB/EiJ	MGP_WSBEiJ_G0022850	protein coding gene	Chr17:33800882-33804581 (+)

Human Ortholog

PSMB8, proteasome 20S subunit beta 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMB8, proteasome 20S subunit beta 8
Synonyms

ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PRAAS1, PSMB5i, RING10
Links

HGNC:9545

NCBI Gene ID: 5696

neXtProt AC: NX_P28062

UniProt: P28062
Chr Location

6p21.32; chr6:32840717-32844679 (-) GRCh38

MGI Vertebrate Homology

Psmb8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMB8
Gene Tree

Psmb8

Diseases

1 with human PSMB8 associations

				Human Disease	Mouse Models
				proteasome-associated autoinflammatory syndrome 1 IDs proteasome-associated autoinflammatory syndrome 1 DOID:0050553 OMIM:256040 ORDO:324999

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
80 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for disruptions in this gene display an essentially normal phenotype. However they have a reduced ability to process MHC class I restricted antigens.

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All GO Annotations

16
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

1
cDNA Data

21
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase psmb8

ZFIN psmb8a

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All Sequences

56
RefSeq

2
UniProt

4
CCDS

CCDS50073.1

Ensembl

ENSMUSG00000024338 (Evidence)
NCBI Gene

16913

			Length	Strain/Species	Flank
genomic	16913	NCBI Gene Model \| MGI Sequence Detail	3260	C57BL/6J	± kb
transcript	NM_010724	RefSeq \| MGI Sequence Detail	1223	ZRU/MplStud
polypeptide	P28063	UniProt \| EBI \| MGI Sequence Detail	276	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013376 proteasome subunit beta type-8

(term hierarchy)
PDB

3UNF, 3UNH, 5L65, 5L66, 5L67, 5L68, 5L69, 5L6A, 5L6B, 5L6C
EC

3.4.25.1
InterPro Domains

IPR029055 Nucleophile aminohydrolases, N-terminal

IPR000243 Peptidase T1A, proteasome beta-subunit

IPR016050 Proteasome beta-type subunit, conserved site

IPR023333 Proteasome B-type subunit

IPR001353 Proteasome, subunit alpha/beta
GlyGen

P28063 1 site, 1 O-linked glycan (1 site)

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All nucleic 24

Genomic 3

cDNA 21

Microarray probesets 4

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MGD-MRK-11822, MGD-MRK-11824, MGI:96798

Summaries

All 130

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 80
Earliest

J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
Latest

J:358431 Su HX, et al., Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation. Cell Death Dis. 2024 Nov 8;15(11):803

TSS for Psmb8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143929	Chr17:34415819-34415832 (+)	-1,343 bp
Tssr143930	Chr17:34416689-34416702 (+)	-473 bp
Tssr5093	Chr17:34416707-34416735 (+)	-448 bp
Tssr143931	Chr17:34417153-34417180 (+)	-2 bp
Tssr143932	Chr17:34417316-34417358 (+)	168 bp
Tssr143933	Chr17:34417359-34417374 (+)	198 bp
Tssr143934	Chr17:34417578-34417594 (+)	417 bp
Tssr143935	Chr17:34419681-34419703 (+)	2,523 bp
Tssr143936	Chr17:34419835-34419846 (+)	2,672 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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