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Esrrb Gene Detail
Summary
  • Symbol
    Esrrb
  • Name
    estrogen related receptor, beta
  • Synonyms
    Err2, ERR2, ERRb, Estrrb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346832
    NCBI Gene: 26380
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:86407891-86568402 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 40.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4515 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346832
 protein coding gene Chr12:86407891-86568402 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019970
 protein coding gene Chr12:87197795-87362961 (+)
A/J MGP_AJ_G0019927
 protein coding gene Chr12:83879682-84049677 (+)
AKR/J MGP_AKRJ_G0019903
 protein coding gene Chr12:86158342-86325090 (+)
BALB/cJ MGP_BALBcJ_G0019907
 protein coding gene Chr12:84218523-84383449 (+)
C3H/HeJ MGP_C3HHeJ_G0019713
 protein coding gene Chr12:86637915-86802496 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020358
 protein coding gene Chr12:89692855-89877957 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017976
 protein coding gene Chr12:80773987-80935599 (+)
CAST/EiJ MGP_CASTEiJ_G0019263
 protein coding gene Chr12:81631575-81803379 (+)
CBA/J MGP_CBAJ_G0019684
 protein coding gene Chr12:93141539-93316226 (+)
DBA/2J MGP_DBA2J_G0019798
 protein coding gene Chr12:83386362-83550260 (+)
FVB/NJ MGP_FVBNJ_G0019785
 protein coding gene Chr12:82363575-82525441 (+)
LP/J MGP_LPJ_G0019872
 protein coding gene Chr12:87071687-87238331 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019824
 protein coding gene Chr12:95934372-96110019 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020391
 protein coding gene Chr12:85782367-85949258 (+)
PWK/PhJ MGP_PWKPhJ_G0019026
 protein coding gene Chr12:77922236-78085949 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018822
 protein coding gene Chr12:80259186-80429096 (+)
WSB/EiJ MGP_WSBEiJ_G0019315
 protein coding gene Chr12:86515125-86684906 (+)



Homology
more
  • Human Ortholog
    ESRRB, estrogen related receptor beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESRRB, estrogen related receptor beta
  • Synonyms
    DFNB35, ERR2, ERRb, ERR beta-2, ERRbeta2, ESRL2, NR3B2
  • Links
    NCBI Gene ID: 2103
    neXtProt AC: NX_O95718
    UniProt: O95718

  • Chr Location
    14q24.3; chr14:76310712-76501837 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Esrrb mouse models; 1 with human ESRRB associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos around E9.5 or E10.5 as a result of failure of the chorion to develop and subsequent placental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1115
  • Tissues
    274
  • cDNA Data
    36
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26380 NCBI Gene Model | MGI Sequence Detail 160512 C57BL/6J ±  kb
    transcript NM_001159500 RefSeq | MGI Sequence Detail 4309 ZRU/MplStud  
    polypeptide Q61539 UniProt | EBI | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000007209 steroid hormone receptor ERR2
      (term hierarchy)
    • InterPro Domains
      IPR024178 Estrogen receptor/oestrogen-related receptor
      IPR001723 Nuclear hormone receptor
      IPR050200 Nuclear hormone receptor family NR3 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR027289 Oestrogen-related receptor
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    • GlyGen
      Q61539 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 2
      cDNA 37
      Primer pair 15
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35849, MGI:107382
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 66
      Diseases 1
      Gene Ontology 28
      Phenotypes 26
    • Earliest
      J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
    • Latest
      J:355264 Festuccia N, et al., Nr5a2 is dispensable for zygotic genome activation but essential for morula development. Science. 2024 Oct 4;386(6717):eadg7325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory