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Mapk1 Gene Detail
Summary
  • Symbol
    Mapk1
  • Name
    mitogen-activated protein kinase 1
  • Synonyms
    9030612K14Rik, Erk2, MAPK2, p42mapk, Prkm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346858
    NCBI Gene: 26413
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16801246-16865317 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1209 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346858
 protein coding gene Chr16:16801246-16865317 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022566
 protein coding gene Chr16:14085904-14154958 (+)
A/J MGP_AJ_G0022527
 protein coding gene Chr16:13391792-13455741 (+)
AKR/J MGP_AKRJ_G0022504
 protein coding gene Chr16:13939085-14008670 (+)
BALB/cJ MGP_BALBcJ_G0022530
 protein coding gene Chr16:13544507-13608575 (+)
C3H/HeJ MGP_C3HHeJ_G0022297
 protein coding gene Chr16:14047807-14116174 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022981
 protein coding gene Chr16:14302672-14374011 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020501
 protein coding gene Chr16:13482323-13543648 (+)
CAST/EiJ MGP_CASTEiJ_G0021825
 protein coding gene Chr16:13975409-14038544 (+)
CBA/J MGP_CBAJ_G0022268
 protein coding gene Chr16:14972074-15043216 (+)
DBA/2J MGP_DBA2J_G0022398
 protein coding gene Chr16:13331453-13395971 (+)
FVB/NJ MGP_FVBNJ_G0022374
 protein coding gene Chr16:13357086-13422585 (+)
LP/J MGP_LPJ_G0022465
 protein coding gene Chr16:13866544-13938442 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022395
 protein coding gene Chr16:14673859-14746282 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022992
 protein coding gene Chr16:13850187-13919539 (+)
PWK/PhJ MGP_PWKPhJ_G0021568
 protein coding gene Chr16:13570309-13635183 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021396
 protein coding gene Chr16:13862061-13926525 (+)
WSB/EiJ MGP_WSBEiJ_G0021872
 protein coding gene Chr16:13869594-13933760 (+)



Homology
more
  • Human Ortholog
    MAPK1, mitogen-activated protein kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK1, mitogen-activated protein kinase 1
  • Synonyms
    ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, p38, p40, p41, p41mapk, p42-MAPK, P42MAPK, PRKM1, PRKM2
  • Links
    NCBI Gene ID: 5594
    neXtProt AC: NX_P28482
    UniProt: P28482

  • Chr Location
    22q11.22; chr22:21759657-21867680 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Mapk1 mouse models; 9 with human MAPK1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    88 phenotypes from 11 alleles in 14 genetic backgrounds
    39 phenotypes from multigenic genotypes
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    170
  • GO References
    77
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1741
  • Tissues
    432
  • cDNA Data
    27
  • Literature Summary
    637
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26413 NCBI Gene Model | MGI Sequence Detail 64072 C57BL/6J ±  kb
    transcript NM_011949 RefSeq | MGI Sequence Detail 5099 ZRU/MplStud  
    polypeptide P63085 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 5
      cDNA 28
      Primer pair 7

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-33596, MGD-MRK-9584, MGI:105919, MGI:1921796, MGI:2146330, MGI:2146551, MGI:2146700
    References
    more
    • Summaries
      All 1140
      Developmental Gene Expression 637
      Diseases 3
      Gene Ontology 77
      Phenotypes 110
    • Earliest
      J:3247 L'Allemain G, et al., Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein. FEBS Lett. 1991 Nov 4;292(1-2):191-5
    • Latest
      J:355327 Blucher RO, et al., VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17. BMC Biol. 2024 Oct 1;22(1):222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory