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Mapk10 Gene Detail
Summary
  • Symbol
    Mapk10
  • Name
    mitogen-activated protein kinase 10
  • Synonyms
    C230008H04Rik, JNK3, p493F12, Serk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346863
    NCBI Gene: 26414
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:103056413-103359200 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 49.61 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9021 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346863
 protein coding gene Chr5:103055814-103359200 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029799
 protein coding gene Chr5:104525140-104826819 (-)
A/J MGP_AJ_G0029763
 protein coding gene Chr5:100600801-100899035 (-)
AKR/J MGP_AKRJ_G0029711
 protein coding gene Chr5:103838118-104146215 (-)
BALB/cJ MGP_BALBcJ_G0029775
 protein coding gene Chr5:101641496-101935967 (-)
C3H/HeJ MGP_C3HHeJ_G0029498
 protein coding gene Chr5:104250865-104552588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030230
 protein coding gene Chr5:108795220-109095812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027465
 protein coding gene Chr5:95773716-96062706 (-)
CAST/EiJ MGP_CASTEiJ_G0028909
 protein coding gene Chr5:102949130-103252986 (-)
CBA/J MGP_CBAJ_G0029468
 protein coding gene Chr5:112605483-112929417 (-)
DBA/2J MGP_DBA2J_G0029612
 protein coding gene Chr5:100790054-101085231 (-)
FVB/NJ MGP_FVBNJ_G0029571
 protein coding gene Chr5:99593043-99895882 (-)
LP/J MGP_LPJ_G0029700
 protein coding gene Chr5:105097904-105399507 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029600
 protein coding gene Chr5:117564358-117877563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030263
 protein coding gene Chr5:103380127-103686833 (-)
PWK/PhJ MGP_PWKPhJ_G0028627
 protein coding gene Chr5:99250637-99537234 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028462
 protein coding gene Chr5:101025725-101316308 (-)
WSB/EiJ MGP_WSBEiJ_G0028987
 protein coding gene Chr5:103736350-104042223 (-)



Homology
more
  • Human Ortholog
    MAPK10, mitogen-activated protein kinase 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK10, mitogen-activated protein kinase 10
  • Synonyms
    JNK3, JNK3A, p493F12, p54bSAPK, PRKM10, SAPK1b
  • Links
    NCBI Gene ID: 5602
    neXtProt AC: NX_P53779
    UniProt: P53779

  • Chr Location
    4q21.3; chr4:85990007-86594625 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAPK10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype. They are resistant to kainic acid induced seizures and show increased resistance to MPTP induced Parkinson's disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1033
  • Tissues
    178
  • cDNA Data
    19
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26414 NCBI Gene Model | MGI Sequence Detail 302788 C57BL/6J ±  kb
    transcript NM_001407592 RefSeq | MGI Sequence Detail 6874 C57BL/6  
    polypeptide Q61831 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 22
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36125, MGI:107554, MGI:2442453
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 22
      Gene Ontology 13
      Phenotypes 59
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:352991 Wang J, et al., Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure. J Biol Chem. 2024 Jul;300(7):107486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory