Mapk13 MGI Mouse Gene Detail - MGI:1346864 - mitogen-activated protein kinase 13

Symbol

Mapk13
Name

mitogen-activated protein kinase 13
Synonyms

p38 delta MAP kinase, SAPK4, Serk4

Feature Type

protein coding gene
IDs

MGI:1346864
NCBI Gene: 26415
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:28988260-28997678 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 15.00 cM, cytoband A3-B
Mapping Data

2 experiments

SNPs within 2kb

89 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346864	protein coding gene	Chr17:28988260-28999207 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023449	protein coding gene	Chr17:28221595-28231865 (+)
A/J	MGP_AJ_G0023407	protein coding gene	Chr17:27270782-27281218 (+)
AKR/J	MGP_AKRJ_G0023372	protein coding gene	Chr17:27481227-27494127 (+)
BALB/cJ	MGP_BALBcJ_G0023412	protein coding gene	Chr17:27548826-27561265 (+)
C3H/HeJ	MGP_C3HHeJ_G0023173	protein coding gene	Chr17:27880079-27889045 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023854	protein coding gene	Chr17:29355190-29366563 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021329	protein coding gene	Chr17:24627936-24637263 (+)
CAST/EiJ	MGP_CASTEiJ_G0022674	protein coding gene	Chr17:27852361-27862638 (+)
CBA/J	MGP_CBAJ_G0023147	protein coding gene	Chr17:30434398-30443475 (+)
DBA/2J	MGP_DBA2J_G0023278	protein coding gene	Chr17:26819731-26829170 (+)
FVB/NJ	MGP_FVBNJ_G0023248	protein coding gene	Chr17:26648040-26657107 (+)
LP/J	MGP_LPJ_G0023356	protein coding gene	Chr17:28470107-28479161 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023266	protein coding gene	Chr17:29818094-29827983 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023896	protein coding gene	Chr17:27924853-27934313 (+)
PWK/PhJ	MGP_PWKPhJ_G0022424	protein coding gene	Chr17:25645833-25656603 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022242	protein coding gene	Chr17:25932703-25941500 (+)
WSB/EiJ	MGP_WSBEiJ_G0022736	protein coding gene	Chr17:27910064-27919933 (+)

Human Ortholog

MAPK13, mitogen-activated protein kinase 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPK13, mitogen-activated protein kinase 13
Synonyms

MAPK 13, MAPK-13, p38delta, PRKM13, SAPK4
Links

HGNC:6875

NCBI Gene ID: 5603

neXtProt AC: NX_O15264

UniProt: O15264
Chr Location

6p21.31; chr6:36127809-36144524 (+) GRCh38

MGI Vertebrate Homology

Mapk13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAPK13
Gene Tree

Mapk13

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Phenotype Summary

11 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin secretion, decreased blood glucose, and decreased susceptibility to diet- or chemically-induced diabetes.

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All GO Annotations

32
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

920
Tissues

44
cDNA Data

51
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapk13

ZFIN mapk13

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All Sequences

59
RefSeq

4
UniProt

9
CCDS

CCDS28584.1

Ensembl

ENSMUSG00000004864 (Evidence)
NCBI Gene

26415

			Length	Strain/Species	Flank
genomic	26415	NCBI Gene Model \| MGI Sequence Detail	9419	C57BL/6J	± kb
transcript	NM_011950	RefSeq \| MGI Sequence Detail	1406	Not Specified
polypeptide	Q9Z1B7	UniProt \| EBI \| MGI Sequence Detail	366	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000010154 mitogen-activated protein kinase 13

(term hierarchy)
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR038785 Mitogen-activated protein kinase 13

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR008352 Mitogen-activated protein (MAP) kinase p38-like

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 55

cDNA 52

Primer pair 3

Microarray probesets 3

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MGI:1195258

Summaries

All 83

Developmental Gene Expression 12

Gene Ontology 10

Phenotypes 38
Earliest

J:38682 Foltz IN, et al., Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway. J Biol Chem. 1997 Feb 7;272(6):3296-301
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mapk13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143464	Chr17:28988301-28988350 (+)	66 bp
Tssr143465	Chr17:28988356-28988359 (+)	98 bp
Tssr143466	Chr17:28988715-28988757 (+)	476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24