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Map3k4 Gene Detail
Summary
  • Symbol
    Map3k4
  • Name
    mitogen-activated protein kinase kinase kinase 4
  • Synonyms
    D17Rp17, D17Rp17e, MAPKKK4, Mekk4, mKIAA0213, MTK1, RP17, Tas, T-associated sex reversal
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346875
    NCBI Gene: 26407
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:12446508-12537683 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.42 cM
  • Mapping Data
    46 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2187 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346875
 protein coding gene Chr17:12446508-12537683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023144
 protein coding gene Chr17:9874102-9963678 (-)
A/J MGP_AJ_G0023112
 protein coding gene Chr17:9721930-9810357 (-)
AKR/J MGP_AKRJ_G0023076
 protein coding gene Chr17:9542603-9636468 (-)
BALB/cJ MGP_BALBcJ_G0023112
 protein coding gene Chr17:9495578-9583174 (-)
C3H/HeJ MGP_C3HHeJ_G0022875
 protein coding gene Chr17:9789980-9879039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023555
 protein coding gene Chr17:10264336-10352177 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021053
 protein coding gene Chr17:4640439-4728638 (+)
CAST/EiJ MGP_CASTEiJ_G0022389
 protein coding gene Chr17:9843852-9934275 (-)
CBA/J MGP_CBAJ_G0022847
 protein coding gene Chr17:10621418-10713706 (-)
DBA/2J MGP_DBA2J_G0022980
 protein coding gene Chr17:9348162-9435537 (-)
FVB/NJ MGP_FVBNJ_G0022950
 protein coding gene Chr17:9298536-9386592 (-)
LP/J MGP_LPJ_G0023052
 protein coding gene Chr17:9684596-9772102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022969
 protein coding gene Chr17:10263979-10352374 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023581
 protein coding gene Chr17:9806312-9897429 (-)
PWK/PhJ MGP_PWKPhJ_G0022137
 protein coding gene Chr17:9046273-9133882 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021967
 protein coding gene Chr17:9212909-9302776 (-)
WSB/EiJ MGP_WSBEiJ_G0022446
 protein coding gene Chr17:10134871-10221935 (-)



Homology
more
  • Human Ortholog
    MAP3K4, mitogen-activated protein kinase kinase kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K4, mitogen-activated protein kinase kinase kinase 4
  • Synonyms
    MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412
  • Links
    NCBI Gene ID: 4216
    neXtProt AC: NX_Q9Y6R4
    UniProt: Q9Y6R4

  • Chr Location
    6q26; chr6:160991727-161117385 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit some perinatal lethality and survivors appear smaller. On certain genetic backgrounds, heterozygous X/Y mice may develop as phenotypic females or hermaphrodites. The sex-reversal phenotype is dependent on a combination of strain-specific autosomal and Y-linked alleles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    30
  • cDNA Data
    99
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26407 NCBI Gene Model | MGI Sequence Detail 91176 C57BL/6J ±  kb
    transcript NM_011948 RefSeq | MGI Sequence Detail 5305 ZRU/MplStud  
    polypeptide O08648 UniProt | EBI | MGI Sequence Detail 1597 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000010137 mitogen-activated protein kinase kinase kinase 4
      (term hierarchy)
    • EC
      2.7.11.25
    • InterPro Domains
      IPR050538 Mitogen-activated protein kinase kinase kinase
      IPR045801 Mitogen-activated protein kinase kinase kinase, N-terminal
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      O08648 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 7
      cDNA 102
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14016, MGD-MRK-14718, MGD-MRK-39591, MGD-MRK-4772, MGD-MRK-4773, MGI:109592, MGI:90953, MGI:98486
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 28
    • Earliest
      J:7073 Washburn LL, et al., Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature. 1983 May 26;303(5915):338-40
    • Latest
      J:326026 Prokopuk L, et al., An essential role for Polycomb Repressive Complex 2 in the mouse ovary. Reproduction. 2022 Feb 17;163(3):167-182
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory