Map3k11 MGI Mouse Gene Detail - MGI:1346880 - mitogen-activated protein kinase kinase kinase 11

Symbol

Map3k11
Name

mitogen-activated protein kinase kinase kinase 11
Synonyms

2610017K16Rik, Mlk3

Feature Type

protein coding gene
IDs

MGI:1346880
NCBI Gene: 26403
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr19:5738770-5752893 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM
Mapping Data

5 experiments

SNPs within 2kb

82 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346880	protein coding gene	Chr19:5738764-5752893 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024722	protein coding gene	Chr19:2673540-2687271 (+)
A/J	MGP_AJ_G0024688	protein coding gene	Chr19:2528257-2541991 (+)
AKR/J	MGP_AKRJ_G0024661	protein coding gene	Chr19:2594696-2608430 (+)
BALB/cJ	MGP_BALBcJ_G0024688	protein coding gene	Chr19:2522652-2536386 (+)
C3H/HeJ	MGP_C3HHeJ_G0024456	protein coding gene	Chr19:2612943-2626677 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025135	protein coding gene	Chr19:2740696-2754919 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022565	protein coding gene	Chr19:2436991-2450802 (+)
CAST/EiJ	MGP_CASTEiJ_G0023928	protein coding gene	Chr19:2632328-2646078 (+)
CBA/J	MGP_CBAJ_G0024428	protein coding gene	Chr19:2866671-2880385 (+)
DBA/2J	MGP_DBA2J_G0024555	protein coding gene	Chr19:2524194-2537908 (+)
FVB/NJ	MGP_FVBNJ_G0024521	protein coding gene	Chr19:2521338-2535437 (+)
LP/J	MGP_LPJ_G0024641	protein coding gene	Chr19:2649498-2663221 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024551	protein coding gene	Chr19:2711237-2724961 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025183	protein coding gene	Chr19:2614932-2628663 (+)
PWK/PhJ	MGP_PWKPhJ_G0023674	protein coding gene	Chr19:2546717-2560509 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023479	protein coding gene	Chr19:2599217-2612955 (+)
WSB/EiJ	MGP_WSBEiJ_G0023990	protein coding gene	Chr19:2624778-2638490 (+)

Human Ortholog

MAP3K11, mitogen-activated protein kinase kinase kinase 11

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K11, mitogen-activated protein kinase kinase kinase 11
Synonyms

MEKK11, MLK-3, MLK3, PTK1, SPRK
Links

HGNC:6850

NCBI Gene ID: 4296

neXtProt AC: NX_Q16584

UniProt: Q16584
Chr Location

11q13.1; chr11:65597756-65615382 (-) GRCh38

MGI Vertebrate Homology

Map3k11 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MAP3K11
Protein SuperFamily

MAPKKK9_11
Gene Tree

Map3k11

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
1 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

2
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted or spontaneous mutation display a pattern of dark red stripes of thin dorsal epithelium during pre-wean development, and necrotic dental pulp has been reported for the spontaneous mutant.

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All GO Annotations

50
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

3
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

15
UniProt

3
CCDS

CCDS29476.1

Ensembl

ENSMUSG00000004054 (Evidence)
NCBI Gene

26403

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004054	Ensembl Gene Model \| MGI Sequence Detail	14124	C57BL/6J	± kb
transcript	ENSMUST00000004156	Ensembl \| MGI Sequence Detail	3898	Not Applicable
polypeptide	ENSMUSP00000004156	Ensembl \| MGI Sequence Detail	850	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010130 mitogen-activated protein kinase kinase kinase 11

(term hierarchy)
EC

2.7.11.25
InterPro Domains

IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4

IPR035779 MLK1-3, SH3 domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050167 Serine/threonine-protein kinase

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 12

Genomic 3

cDNA 8

Other 1

Microarray probesets 3

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MGI:1095739, MGI:1923791

Summaries

All 66

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 22
Earliest

J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
Latest

J:330866 Liu PW, et al., Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function. Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H513-H522

TSS for Map3k11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154475	Chr19:5738751-5738798 (+)	5 bp
Tssr154476	Chr19:5738806-5738825 (+)	46 bp
Tssr154477	Chr19:5739773-5739851 (+)	1,042 bp
Tssr154478	Chr19:5742880-5742902 (+)	4,121 bp
Tssr154479	Chr19:5750798-5750823 (+)	12,041 bp

Map3k11 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Mtes1	Chr19, syntenic		J:103849	The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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