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Map3k12 Gene Detail
Summary
  • Symbol
    Map3k12
  • Name
    mitogen-activated protein kinase kinase kinase 12
  • Synonyms
    DLK, MUK, Zpk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346881
    NCBI Gene: 26404
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102406079-102425311 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.63 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346881
 protein coding gene Chr15:102406079-102425499 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022416
 protein coding gene Chr15:104687379-104706870 (-)
A/J MGP_AJ_G0022378
 protein coding gene Chr15:100562177-100581596 (-)
AKR/J MGP_AKRJ_G0022353
 protein coding gene Chr15:103607328-103626744 (-)
BALB/cJ MGP_BALBcJ_G0022382
 protein coding gene Chr15:100617474-100637187 (-)
C3H/HeJ MGP_C3HHeJ_G0022149
 protein coding gene Chr15:103685344-103705877 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022831
 protein coding gene Chr15:108584697-108604750 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020354
 protein coding gene Chr15:96340599-96358448 (-)
CAST/EiJ MGP_CASTEiJ_G0021675
 protein coding gene Chr15:104564588-104584681 (-)
CBA/J MGP_CBAJ_G0022118
 protein coding gene Chr15:112395279-112414700 (-)
DBA/2J MGP_DBA2J_G0022249
 protein coding gene Chr15:99845822-99865359 (-)
FVB/NJ MGP_FVBNJ_G0022225
 protein coding gene Chr15:98907875-98927298 (-)
LP/J MGP_LPJ_G0022318
 protein coding gene Chr15:104837226-104856614 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022247
 protein coding gene Chr15:115948997-115968431 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022843
 protein coding gene Chr15:103649523-103673146 (-)
PWK/PhJ MGP_PWKPhJ_G0021415
 protein coding gene Chr15:100010758-100031135 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021247
 protein coding gene Chr15:103491992-103512119 (-)
WSB/EiJ MGP_WSBEiJ_G0021725
 protein coding gene Chr15:104275040-104297233 (-)



Homology
more
  • Human Ortholog
    MAP3K12, mitogen-activated protein kinase kinase kinase 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K12, mitogen-activated protein kinase kinase kinase 12
  • Synonyms
    DLK, HP09298, MEKK12, MUK, ZPK, ZPKP1
  • Links
    NCBI Gene ID: 7786
    neXtProt AC: NX_Q12852
    UniProt: Q12852

  • Chr Location
    12q13.13; chr12:53479669-53501539 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 8 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele lack the brain anterior commissure. Mice homozygous for a knock-out allele exhibit postnatal lethality and abnormal axon growth and radial migration of neocortical pyramidal neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    234
  • cDNA Data
    23
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26404 NCBI Gene Model | MGI Sequence Detail 19233 C57BL/6J ±  kb
    transcript NM_001358844 RefSeq | MGI Sequence Detail 5450 C57BL/6  
    polypeptide Q60700 UniProt | EBI | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000010131 mitogen-activated protein kinase kinase kinase 12
      (term hierarchy)
    • EC
      2.7.11.25
    • InterPro Domains
      IPR027257 Mitogen-activated protein kinase kinase kinase 12
      IPR017419 Mitogen-activated protein kinase kinase kinase 12/13
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050167 Serine/threonine-protein kinase
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19592, MGI:102689
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 12
      Phenotypes 61
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:348799 Asghari Adib E, et al., DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses. Cell Rep. 2024 Feb 27;43(2):113801
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory