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Angptl2 Gene Detail
Summary
  • Symbol
    Angptl2
  • Name
    angiopoietin-like 2
  • Synonyms
    Arp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347002
    NCBI Gene: 26360
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:33106081-33137729 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    672 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347002
 protein coding gene Chr2:33105963-33137737 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025632
 protein coding gene Chr2:31730801-31762442 (+)
A/J MGP_AJ_G0025609
 protein coding gene Chr2:30377150-30408800 (+)
AKR/J MGP_AKRJ_G0025579
 protein coding gene Chr2:31457208-31490235 (+)
BALB/cJ MGP_BALBcJ_G0025606
 protein coding gene Chr2:30497086-30528736 (+)
C3H/HeJ MGP_C3HHeJ_G0025366
 protein coding gene Chr2:31350053-31381703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026050
 protein coding gene Chr2:32670536-32702196 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023459
 protein coding gene Chr2:29106524-29138360 (+)
CAST/EiJ MGP_CASTEiJ_G0024828
 protein coding gene Chr2:31316403-31348032 (+)
CBA/J MGP_CBAJ_G0025344
 protein coding gene Chr2:33917736-33949384 (+)
DBA/2J MGP_DBA2J_G0025477
 protein coding gene Chr2:30139752-30171392 (+)
FVB/NJ MGP_FVBNJ_G0025439
 protein coding gene Chr2:30034445-30066341 (+)
LP/J MGP_LPJ_G0025563
 protein coding gene Chr2:31615349-31647250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025470
 protein coding gene Chr2:33519543-33551202 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026108
 protein coding gene Chr2:31345674-31377288 (+)
PWK/PhJ MGP_PWKPhJ_G0024576
 protein coding gene Chr2:30055357-30087527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024376
 protein coding gene Chr2:31504056-31537246 (+)
WSB/EiJ MGP_WSBEiJ_G0024897
 protein coding gene Chr2:31528072-31559720 (+)



Homology
more
  • Human Ortholog
    ANGPTL2, angiopoietin like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPTL2, angiopoietin like 2
  • Synonyms
    ARP2, HARP
  • Links
    NCBI Gene ID: 23452
    neXtProt AC: NX_Q9UKU9
    UniProt: Q9UKU9

  • Chr Location
    9q33.3; chr9:127087348-127122635 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Angptl2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
When fed a high-fat diet, mice homozygous for a knock-out allele show decreased weight gain, reduced adipocity, a lower respiratory quotient, reduced inflammation in adipose tissues, enhanced glucose tolerance, and increased insulin sensitivity in both skeletal muscle and liver relative to controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1030
  • Tissues
    33
  • cDNA Data
    77
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004105 Ensembl Gene Model | MGI Sequence Detail 31649 C57BL/6J ±  kb
    transcript ENSMUST00000004208 Ensembl | MGI Sequence Detail 3339 Not Applicable  
    polypeptide ENSMUSP00000004208 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004027 angiopoietin-related protein 2
      (term hierarchy)
    • InterPro Domains
      IPR037579 Fibrinogen
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR050373 Fibrinogen C-terminal domain-containing protein
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      Q9R045 2 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139009, MGI:2139338
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 3
      Phenotypes 26
    • Earliest
      J:57564 Kim I, et al., Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. J Biol Chem. 1999 Sep 10;274(37):26523-8
    • Latest
      J:340727 Horiguchi H, et al., ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis. Commun Biol. 2023 Sep 22;6(1):965
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory