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Txnrd2 Gene Detail
Summary
  • Symbol
    Txnrd2
  • Name
    thioredoxin reductase 2
  • Synonyms
    ESTM573010, TGR, TR3, TR beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347023
    NCBI Gene: 26462
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18245167-18297823 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.41 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347023
 protein coding gene Chr16:18245134-18297823 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022611
 protein coding gene Chr16:15651958-15710043 (+)
A/J MGP_AJ_G0022572
 protein coding gene Chr16:14876221-14929186 (+)
AKR/J MGP_AKRJ_G0022549
 protein coding gene Chr16:15468463-15522488 (+)
BALB/cJ MGP_BALBcJ_G0022577
 protein coding gene Chr16:15024551-15077663 (+)
C3H/HeJ MGP_C3HHeJ_G0022344
 protein coding gene Chr16:15616989-15672685 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023026
 protein coding gene Chr16:15933959-15990714 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020546
 protein coding gene Chr16:14910923-14964409 (+)
CAST/EiJ MGP_CASTEiJ_G0021871
 protein coding gene Chr16:15520380-15576308 (+)
CBA/J MGP_CBAJ_G0022313
 protein coding gene Chr16:16642548-16703665 (+)
DBA/2J MGP_DBA2J_G0022445
 protein coding gene Chr16:14791983-14844515 (+)
FVB/NJ MGP_FVBNJ_G0022420
 protein coding gene Chr16:14848682-14903690 (+)
LP/J MGP_LPJ_G0022512
 protein coding gene Chr16:15419816-15473109 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022442
 protein coding gene Chr16:16268386-16325289 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023037
 protein coding gene Chr16:15399509-15453131 (+)
PWK/PhJ MGP_PWKPhJ_G0021613
 protein coding gene Chr16:15059384-15113242 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021441
 protein coding gene Chr16:15356017-15412249 (+)
WSB/EiJ MGP_WSBEiJ_G0021917
 protein coding gene Chr16:15395557-15448685 (+)



Homology
more
  • Human Ortholog
    TXNRD2, thioredoxin reductase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNRD2, thioredoxin reductase 2
  • Synonyms
    GCCD5, SELZ, TR, TR3, TR-BETA, TRXR2, TXNR2
  • Links
    NCBI Gene ID: 10587
    neXtProt AC: NX_Q9NNW7
    UniProt: Q9NNW7

  • Chr Location
    22q11.21; chr22:19875517-19941820 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TXNRD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die at E13 due to severe anemia and growth retardation, resulting from perturbed cardiac development and augmented apoptosis of hematopoietic cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    135
  • cDNA Data
    9
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26462 NCBI Gene Model | MGI Sequence Detail 52657 C57BL/6J ±  kb
    transcript NM_013711 RefSeq | MGI Sequence Detail 1922 ZRU/MplStud  
    polypeptide Q9JLT4 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000016872 thioredoxin reductase 2, mitochondrial
      (term hierarchy)
    • PDB
      1ZDL, 1ZKQ, 3DGZ
    • EC
      1.8.1.9
    • InterPro Domains
      IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
      IPR023753 FAD/NAD(P)-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR046952 Glutathione reductase/thioredoxin reductase-like
      IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class I
      IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
      IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
      IPR006338 Thioredoxin/glutathione reductase selenoprotein
    • GlyGen
      Q9JLT4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 5
      cDNA 11
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1338029
    References
    more
    • Summaries
      All 190
      Developmental Gene Expression 10
      Diseases 6
      Gene Ontology 11
      Phenotypes 138
    • Earliest
      J:54501 Lund J, et al., Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2. Mamm Genome. 1999 May;10(5):438-43
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory