Vnn3 MGI Mouse Gene Detail - MGI:1347055

Symbol

Vnn3
Name

vanin 3

Feature Type

protein coding gene
IDs

MGI:1347055
NCBI Gene: 26464
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:23727360-23745741 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 11.24 cM, cytoband A2-B1
Mapping Data

3 experiments

SNPs within 2kb

580 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347055	protein coding gene	Chr10:23727360-23745741 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017074	protein coding gene	Chr10:21779550-21797946 (+)
A/J	MGP_AJ_G0017052	protein coding gene	Chr10:21155719-21168103 (+)
AKR/J	MGP_AKRJ_G0017014	protein coding gene	Chr10:21501121-21513505 (+)
BALB/cJ	MGP_BALBcJ_G0017014	protein coding gene	Chr10:21230030-21242414 (+)
C3H/HeJ	MGP_C3HHeJ_G0016834	protein coding gene	Chr10:21703493-21715877 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017472	protein coding gene	Chr10:22429939-22442665 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015173	protein coding gene	Chr10:19884238-19896933 (+)
CAST/EiJ	MGP_CASTEiJ_G0016415	protein coding gene	Chr10:21599169-21612271 (+)
CBA/J	MGP_CBAJ_G0016807	protein coding gene	Chr10:23428267-23448594 (+)
DBA/2J	MGP_DBA2J_G0016913	protein coding gene	Chr10:20886419-20903871 (+)
FVB/NJ	MGP_FVBNJ_G0016909	protein coding gene	Chr10:20610970-20623346 (+)
LP/J	MGP_LPJ_G0016989	protein coding gene	Chr10:21764096-21780054 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016939	protein coding gene	Chr10:23581564-23594943 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017507	protein coding gene	Chr10:21357231-21371228 (+)
PWK/PhJ	MGP_PWKPhJ_G0016200	protein coding gene	Chr10:20630201-20646595 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015982	protein coding gene	Chr10:21167958-21194465 (+)
WSB/EiJ	MGP_WSBEiJ_G0016478	protein coding gene	Chr10:21467575-21479897 (+)

Human Ortholog

VNN3P, vanin 3, pseudogene

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VNN3P, vanin 3, pseudogene
Synonyms

HSA238982, VNN3
Links

HGNC:16431

NCBI Gene ID: 55350
Chr Location

6q23.2; chr6:132722784-132736935 (-) GRCh38

MGI Vertebrate Homology

Vnn3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: VNN3P
Protein SuperFamily

Biotinidase
Gene Tree

Vnn3

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Vnn3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

811
Tissues

100
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS23734.1

Ensembl

ENSMUSG00000020010 (Evidence)
NCBI Gene

26464

			Length	Strain/Species	Flank
genomic	26464	NCBI Gene Model \| MGI Sequence Detail	18382	C57BL/6J	± kb
transcript	NM_011979	RefSeq \| MGI Sequence Detail	1811	C57BL/6
polypeptide	Q9QZ25	UniProt \| EBI \| MGI Sequence Detail	500	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR012101 Biotinidase-like, eukaryotic

IPR040154 Biotinidase/VNN family

IPR003010 Carbon-nitrogen hydrolase

IPR036526 Carbon-nitrogen hydrolase superfamily

IPR043957 Vanin, C-terminal
GlyGen

Q9QZ25 5 sites

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All nucleic 12

Genomic 1

cDNA 8

Primer pair 3

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vnn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92711	Chr10:23727325-23727351 (+)	-22 bp
Tssr92712	Chr10:23727352-23727387 (+)	10 bp
Tssr92713	Chr10:23727393-23727405 (+)	39 bp
Tssr92714	Chr10:23727420-23727431 (+)	66 bp
Tssr92715	Chr10:23727435-23727446 (+)	81 bp
Tssr92716	Chr10:23727455-23727478 (+)	107 bp
Tssr92717	Chr10:23727647-23727672 (+)	300 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24