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Decr2 Gene Detail
Summary
  • Symbol
    Decr2
  • Name
    2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347059
    NCBI Gene: 26378
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:26300182-26309096 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.06 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347059
 protein coding gene Chr17:26300182-26309311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023388
 protein coding gene Chr17:25209348-25219674 (-)
A/J MGP_AJ_G0023347
 protein coding gene Chr17:24468521-24477655 (-)
AKR/J MGP_AKRJ_G0023313
 protein coding gene Chr17:24575543-24586137 (-)
BALB/cJ MGP_BALBcJ_G0023352
 protein coding gene Chr17:24690243-24700147 (-)
C3H/HeJ MGP_C3HHeJ_G0023112
 protein coding gene Chr17:24966445-24975968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023794
 protein coding gene Chr17:26275367-26284769 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021270
 protein coding gene Chr17:21919595-21929720 (-)
CAST/EiJ MGP_CASTEiJ_G0022614
 protein coding gene Chr17:24860761-24871919 (-)
CBA/J MGP_CBAJ_G0023087
 protein coding gene Chr17:27203537-27214269 (-)
DBA/2J MGP_DBA2J_G0023217
 protein coding gene Chr17:24062972-24072149 (-)
FVB/NJ MGP_FVBNJ_G0023187
 protein coding gene Chr17:23819866-23829611 (-)
LP/J MGP_LPJ_G0023294
 protein coding gene Chr17:25496372-25508220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023206
 protein coding gene Chr17:26772992-26784961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023834
 protein coding gene Chr17:24907080-24918365 (-)
PWK/PhJ MGP_PWKPhJ_G0022363
 protein coding gene Chr17:22832898-22841915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022181
 protein coding gene Chr17:22984160-22996779 (-)
WSB/EiJ MGP_WSBEiJ_G0022677
 protein coding gene Chr17:24948550-24958326 (-)



Homology
more
  • Human Ortholog
    DECR2, 2,4-dienoyl-CoA reductase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DECR2, 2,4-dienoyl-CoA reductase 2
  • Synonyms
    PDCR, SDR17C1
  • Links
    NCBI Gene ID: 26063
    neXtProt AC: NX_Q9NUI1
    UniProt: Q9NUI1

  • Chr Location
    16p13.3; chr16:401858-412487 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26378 NCBI Gene Model | MGI Sequence Detail 8915 C57BL/6J ±  kb
    transcript NM_001411311 RefSeq | MGI Sequence Detail 2017 ZRU/MplStud  
    polypeptide Q9WV68 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000006374 peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
      (term hierarchy)
    • EC
      1.3.1.124
    • InterPro Domains
      IPR036291 NAD(P)-binding domain superfamily
      IPR045017 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
      IPR002347 Short-chain dehydrogenase/reductase SDR
    • GlyGen
      Q9WV68 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:57230 Geisbrecht BV, et al., The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase. J Biol Chem. 1999 Sep 3;274(36):25814-20
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory