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Abcg2 Gene Detail
Summary
  • Symbol
    Abcg2
  • Name
    ATP binding cassette subfamily G member 2 (Junior blood group)
  • Synonyms
    4930430M16Rik, Bcrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347061
    NCBI Gene: 26357
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:58561476-58669436 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6,
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2855 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347061
 protein coding gene Chr6:58561476-58672661 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030817
 protein coding gene Chr6:58196013-58334429 (+)
A/J MGP_AJ_G0030784
 protein coding gene Chr6:55666931-55808514 (+)
AKR/J MGP_AKRJ_G0030712
 protein coding gene Chr6:57530605-57643778 (+)
BALB/cJ MGP_BALBcJ_G0030794
 protein coding gene Chr6:55503935-56094813 (+)
C3H/HeJ MGP_C3HHeJ_G0030510
 protein coding gene Chr6:57490690-57619655 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031254
 protein coding gene Chr6:59514475-59613300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028446
 protein coding gene Chr6:52712497-52828954 (+)
CAST/EiJ MGP_CASTEiJ_G0029908
 protein coding gene Chr6:57121176-57268641 (+)
CBA/J MGP_CBAJ_G0030483
 protein coding gene Chr6:62053744-62124221 (+)
DBA/2J MGP_DBA2J_G0030634
 protein coding gene Chr6:55368566-55514498 (+)
FVB/NJ MGP_FVBNJ_G0030583
 protein coding gene Chr6:54543175-55059531 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031280
 protein coding gene Chr6:57366853-57497323 (+)
PWK/PhJ MGP_PWKPhJ_G0029623
 protein coding gene Chr6:55103834-55259311 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029448
 protein coding gene Chr6:56188128-56724951 (+)
WSB/EiJ MGP_WSBEiJ_G0029989
 protein coding gene Chr6:57584332-57698803 (+)



Homology
more
  • Human Ortholog
    ABCG2, ATP binding cassette subfamily G member 2 (JR blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCG2, ATP binding cassette subfamily G member 2 (JR blood group)
  • Synonyms
    ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, CDw388, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1
  • Links
    NCBI Gene ID: 9429
    neXtProt AC: NX_Q9UNQ0
    UniProt: Q9UNQ0

  • Chr Location
    4q22.1; chr4:88090150-88231628 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Abcg2 mouse models; 6 with human ABCG2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit extreme sensitivity to the dietary chlorophyll-catabolite pheophorbide a, resulting in severe phototoxic skin lesions upon light exposure. Mutants show a novel form of protoporphyria, associated with a 10-fold increase in erythrocyte levels of protoporphyrin IX.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    961
  • Tissues
    189
  • cDNA Data
    33
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26357 NCBI Gene Model | MGI Sequence Detail 107961 C57BL/6J ±  kb
    transcript NM_011920 RefSeq | MGI Sequence Detail 2493 ZRU/MplStud  
    polypeptide Q7TMS5 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 33
      Primer pair 9
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921131, MGI:2141405
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 11
      Diseases 3
      Gene Ontology 11
      Phenotypes 80
    • Earliest
      J:56609 Allikmets R, et al., A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 1998 Dec 1;58(23):5337-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory