Dapp1 MGI Mouse Gene Detail - MGI:1347063 - dual adaptor for phosphotyrosine and 3-phosphoinositides 1

Symbol

Dapp1
Name

dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Synonyms

Bam32

Feature Type

protein coding gene
IDs

MGI:1347063
NCBI Gene: 26377
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:137636768-137687306 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 63.98 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

1369 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347063	protein coding gene	Chr3:137636768-137687331 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027921	protein coding gene	Chr3:140961187-141018485 (-)
A/J	MGP_AJ_G0027878	protein coding gene	Chr3:135978134-136028664 (-)
AKR/J	MGP_AKRJ_G0027844	protein coding gene	Chr3:139594313-139646708 (-)
BALB/cJ	MGP_BALBcJ_G0027890	protein coding gene	Chr3:135786845-135839235 (-)
C3H/HeJ	MGP_C3HHeJ_G0027620	protein coding gene	Chr3:139923972-139976650 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028334	protein coding gene	Chr3:145826031-145879219 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025672	protein coding gene	Chr3:131080982-131131332 (-)
CAST/EiJ	MGP_CASTEiJ_G0027076	protein coding gene	Chr3:139683127-139739085 (-)
CBA/J	MGP_CBAJ_G0027597	protein coding gene	Chr3:150783514-150838466 (-)
DBA/2J	MGP_DBA2J_G0027736	protein coding gene	Chr3:135101077-135151501 (-)
FVB/NJ	MGP_FVBNJ_G0027703	protein coding gene	Chr3:132560925-132612411 (-)
LP/J	MGP_LPJ_G0027846	protein coding gene	Chr3:142368268-142422423 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027735	protein coding gene	Chr3:158888689-158944219 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028392	protein coding gene	Chr3:139137087-139190607 (-)
PWK/PhJ	MGP_PWKPhJ_G0026800	protein coding gene	Chr3:134852389-134905096 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026627	protein coding gene	Chr3:137223700-137275583 (-)
WSB/EiJ	MGP_WSBEiJ_G0027155	protein coding gene	Chr3:139953410-140008096 (-)

Human Ortholog

DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Synonyms

BAM32
Links

HGNC:16500

NCBI Gene ID: 27071

neXtProt AC: NX_Q9UN19

UniProt: Q9UN19
Chr Location

4q23; chr4:99816827-99872333 (+) GRCh38

MGI Vertebrate Homology

Dapp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DAPP1
Gene Tree

Dapp1

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

25
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Dapp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this gene invokes immune defects stemming from impaired B cell receptor crosslinking.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

4
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dapp1

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All Sequences

56
RefSeq

8
UniProt

4
CCDS

CCDS17864.1, CCDS80029.1

Ensembl

ENSMUSG00000028159 (Evidence)
NCBI Gene

26377

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028159	Ensembl Gene Model \| MGI Sequence Detail	50539	C57BL/6J	± kb
transcript	ENSMUST00000029806	Ensembl \| MGI Sequence Detail	3083	Not Applicable
polypeptide	ENSMUSP00000029806	Ensembl \| MGI Sequence Detail	280	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006280 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

(term hierarchy)
InterPro Domains

IPR035843 DAPP1, SH2 domain

IPR011993 PH-like domain superfamily

IPR051707 Phosphoinositide-Interacting Signal Transduction Regulators

IPR001849 Pleckstrin homology domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

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All nucleic 11

cDNA 11

Microarray probesets 4

Summaries

All 46

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 21
Earliest

J:57026 Dowler S, et al., DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J. 1999 Aug 15;342(Pt 1):7-12
Latest

J:304602 Hao L, et al., Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2021 Feb 12;22(4)

TSS for Dapp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35869	Chr3:137687309-137687325 (-)	-11 bp
Tssr35868	Chr3:137687284-137687303 (-)	12 bp
Tssr35867	Chr3:137687266-137687283 (-)	31 bp
Tssr35866	Chr3:137687244-137687255 (-)	56 bp
Tssr35865	Chr3:137675397-137675401 (-)	11,907 bp
Tssr35864	Chr3:137671753-137671762 (-)	15,548 bp
Tssr35863	Chr3:137660535-137660536 (-)	26,770 bp
Tssr35862	Chr3:137660500-137660519 (-)	26,796 bp
Tssr35861	Chr3:137660489-137660497 (-)	26,813 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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