About   Help   FAQ
Dapp1 Gene Detail
Summary
  • Symbol
    Dapp1
  • Name
    dual adaptor for phosphotyrosine and 3-phosphoinositides 1
  • Synonyms
    Bam32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347063
    NCBI Gene: 26377
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:137636768-137687306 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 63.98 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1369 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347063
 protein coding gene Chr3:137636768-137687331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027921
 protein coding gene Chr3:140961187-141018485 (-)
A/J MGP_AJ_G0027878
 protein coding gene Chr3:135978134-136028664 (-)
AKR/J MGP_AKRJ_G0027844
 protein coding gene Chr3:139594313-139646708 (-)
BALB/cJ MGP_BALBcJ_G0027890
 protein coding gene Chr3:135786845-135839235 (-)
C3H/HeJ MGP_C3HHeJ_G0027620
 protein coding gene Chr3:139923972-139976650 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028334
 protein coding gene Chr3:145826031-145879219 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025672
 protein coding gene Chr3:131080982-131131332 (-)
CAST/EiJ MGP_CASTEiJ_G0027076
 protein coding gene Chr3:139683127-139739085 (-)
CBA/J MGP_CBAJ_G0027597
 protein coding gene Chr3:150783514-150838466 (-)
DBA/2J MGP_DBA2J_G0027736
 protein coding gene Chr3:135101077-135151501 (-)
FVB/NJ MGP_FVBNJ_G0027703
 protein coding gene Chr3:132560925-132612411 (-)
LP/J MGP_LPJ_G0027846
 protein coding gene Chr3:142368268-142422423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027735
 protein coding gene Chr3:158888689-158944219 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028392
 protein coding gene Chr3:139137087-139190607 (-)
PWK/PhJ MGP_PWKPhJ_G0026800
 protein coding gene Chr3:134852389-134905096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026627
 protein coding gene Chr3:137223700-137275583 (-)
WSB/EiJ MGP_WSBEiJ_G0027155
 protein coding gene Chr3:139953410-140008096 (-)



Homology
more
  • Human Ortholog
    DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  • Synonyms
    BAM32
  • Links
    NCBI Gene ID: 27071
    neXtProt AC: NX_Q9UN19
    UniProt: Q9UN19

  • Chr Location
    4q23; chr4:99816827-99872333 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene invokes immune defects stemming from impaired B cell receptor crosslinking.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    4
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028159 Ensembl Gene Model | MGI Sequence Detail 50539 C57BL/6J ±  kb
    transcript ENSMUST00000029806 Ensembl | MGI Sequence Detail 3083 Not Applicable  
    polypeptide ENSMUSP00000029806 Ensembl | MGI Sequence Detail 280 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:57026 Dowler S, et al., DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J. 1999 Aug 15;342(Pt 1):7-12
    • Latest
      J:304602 Hao L, et al., Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2021 Feb 12;22(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory