Zfp260 MGI Mouse Gene Detail - MGI:1347071

Symbol

Zfp260
Name

zinc finger protein 260
Synonyms

Ozrf1, PEX1, Zfp63

Feature Type

protein coding gene
IDs

MGI:1347071
NCBI Gene: 26466
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:29794207-29807047 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 17.26 cM
Mapping Data

6 experiments

SNPs within 2kb

456 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347071	protein coding gene	Chr7:29794202-29807047 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032000	protein coding gene	Chr7:29057921-29070886 (+)
A/J	MGP_AJ_G0031977	protein coding gene	Chr7:28301604-28314079 (+)
AKR/J	MGP_AKRJ_G0031910	protein coding gene	Chr7:29018099-29031421 (+)
BALB/cJ	MGP_BALBcJ_G0031984	protein coding gene	Chr7:28474900-28487504 (+)
C3H/HeJ	MGP_C3HHeJ_G0031703	protein coding gene	Chr7:29468324-29481060 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032449	protein coding gene	Chr7:29994637-30009854 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029500	protein coding gene	Chr7:29328044-29342851 (+)
CAST/EiJ	MGP_CASTEiJ_G0031037	protein coding gene	Chr7:22700182-22715137 (+)
CBA/J	MGP_CBAJ_G0031669	protein coding gene	Chr7:31449312-31463644 (+)
DBA/2J	MGP_DBA2J_G0031821	protein coding gene	Chr7:28027807-28040738 (+)
FVB/NJ	MGP_FVBNJ_G0031778	protein coding gene	Chr7:28145735-28158818 (+)
LP/J	MGP_LPJ_G0031902	protein coding gene	Chr7:29386828-29400276 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031814	protein coding gene	Chr7:30712200-30731598 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032478	protein coding gene	Chr7:28508615-28525172 (+)
PWK/PhJ	MGP_PWKPhJ_G0030763	protein coding gene	Chr7:23055663-23068937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030596	protein coding gene	Chr7:19506628-19521559 (+)
WSB/EiJ	MGP_WSBEiJ_G0031147	protein coding gene	Chr7:28898765-28911231 (+)

Human Ortholog

ZNF260, zinc finger protein 260

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF260, zinc finger protein 260
Synonyms

OZRF1, PEX1, ZFP260
Links

HGNC:13499

NCBI Gene ID: 339324

neXtProt AC: NX_Q3ZCT1

UniProt: Q3ZCT1
Chr Location

19q13.12; chr19:36510687-36528271 (-) GRCh38

MGI Vertebrate Homology

Zfp260 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: ZNF260
Gene Tree

Zfp260

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

2
Gene trapped

46
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

58
cDNA Data

77
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

6
UniProt

3
CCDS

CCDS21078.1

Ensembl

ENSMUSG00000049421 (Evidence)
NCBI Gene

26466

			Length	Strain/Species	Flank
genomic	26466	NCBI Gene Model \| MGI Sequence Detail	12841	C57BL/6J	± kb
transcript	NM_011981	RefSeq \| MGI Sequence Detail	3851	ZRU/MplStud
polypeptide	Q62513	UniProt \| EBI \| MGI Sequence Detail	407	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017787 zinc finger protein 260

(term hierarchy)
InterPro Domains

IPR050826 Krueppel C2H2-type Zinc Finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 79

Genomic 1

cDNA 77

Primer pair 1

Microarray probesets 9

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MGD-MRK-16446, MGI:2141984, MGI:99661

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 9
Earliest

J:26632 Danciger M, et al., Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens. Genomics. 1995 Jul 1;28(1):39-43
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp260:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65655	Chr7:29794575-29794617 (+)	389 bp
Tssr65656	Chr7:29798982-29799039 (+)	4,804 bp
Tssr2181	Chr7:29800266-29800268 (+)	6,060 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24