Rpl27a MGI Mouse Gene Detail - MGI:1347076

Symbol

Rpl27a
Name

ribosomal protein L27A
Synonyms

L27', L27A, ribosomal protein L29 homolog (yeast)

Feature Type

protein coding gene
IDs

MGI:1347076
NCBI Gene: 26451
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:109118354-109121574 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.26 cM, cytoband E2-F1
Mapping Data

3 experiments

SNPs within 2kb

205 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347076	protein coding gene	Chr7:109118354-109121967 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032842	protein coding gene	Chr7:112947539-112950766 (+)
A/J	MGP_AJ_G0032826	protein coding gene	Chr7:110160794-110164827 (+)
AKR/J	MGP_AKRJ_G0032757	protein coding gene	Chr7:112927225-112931901 (+)
BALB/cJ	MGP_BALBcJ_G0032830	protein coding gene	Chr7:109857902-109861119 (+)
C3H/HeJ	MGP_C3HHeJ_G0032540	protein coding gene	Chr7:112956641-112959860 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033336	protein coding gene	Chr7:117632609-117637244 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030309	protein coding gene	Chr7:111732170-111735309 (+)
CAST/EiJ	MGP_CASTEiJ_G0031868	protein coding gene	Chr7:104484301-104487518 (+)
CBA/J	MGP_CBAJ_G0032513	protein coding gene	Chr7:121492122-121497925 (+)
DBA/2J	MGP_DBA2J_G0032665	protein coding gene	Chr7:108271982-108275244 (+)
FVB/NJ	MGP_FVBNJ_G0032618	protein coding gene	Chr7:108119429-108122622 (+)
LP/J	MGP_LPJ_G0032759	protein coding gene	Chr7:114477923-114481187 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032650	protein coding gene	Chr7:123150961-123154185 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033357	protein coding gene	Chr7:111933762-111937409 (+)
PWK/PhJ	MGP_PWKPhJ_G0031575	protein coding gene	Chr7:101069750-101073161 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031423	protein coding gene	Chr7:98620499-98623760 (+)
WSB/EiJ	MGP_WSBEiJ_G0031981	protein coding gene	Chr7:112776651-112781684 (+)

Human Ortholog

RPL27A, ribosomal protein L27a

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL27A, ribosomal protein L27a
Synonyms

L27A, uL15
Links

HGNC:10329

NCBI Gene ID: 6157

neXtProt AC: NX_P46776

UniProt: P46776
Chr Location

11p15.4; chr11:8682788-8714759 (+) GRCh38

MGI Vertebrate Homology

Rpl27a stringent orthology
1 human;1 mouse;3 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL27A
Gene Tree

Rpl27a

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Phenotype Summary

33 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

37
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Rpl27a
Incidental Mutations

APF
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for an ENU-induced allele die before E7.5. Heterozygotes show partial postnatal lethality, retarded growth, cerebellar ataxia, small cerebella, spleens and thymi, hyperpigmentation of the tail, feet, ears and genital areas, pancytopenia, anemia, and high sensitivity to gamma-irradiation.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

428
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl27a

ZFIN rpl27a

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All Sequences

56
RefSeq

2
UniProt

2
CCDS

CCDS40083.1

Ensembl

ENSMUSG00000046364 (Evidence)
NCBI Gene

26451

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046364	Ensembl Gene Model \| MGI Sequence Detail	3221	C57BL/6J	± kb
transcript	ENSMUST00000143107	Ensembl \| MGI Sequence Detail	1158	Not Applicable
polypeptide	ENSMUSP00000123410	Ensembl \| MGI Sequence Detail	148	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014209 eukaryotic-type large ribosomal subunit protein uL15

(term hierarchy)
PDB

6SWA, 7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR030878 Large ribosomal subunit protein uL15

IPR001196 Large ribosomal subunit protein uL15, conserved site

IPR021131 Large ribosomal subunit protein uL15/eL18

IPR036227 Large ribosomal subunit protein uL15/eL18 superfamily

IPR027386 Ribosomal uL15, N-terminal
GlyGen

P14115 1 site, 1 O-linked glycan (1 site)

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All nucleic 430

Genomic 2

cDNA 428

Microarray probesets 14

Summaries

All 54

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 20
Earliest

J:8614 Belhumeur P, et al., Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Nucleic Acids Res. 1987 Feb 11;15(3):1019-29
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rpl27a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68470	Chr7:109118346-109118449 (+)	44 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24