Anxa10 MGI Mouse Gene Detail - MGI:1347090

Symbol

Anxa10
Name

annexin A10

Feature Type

protein coding gene
IDs

MGI:1347090
NCBI Gene: 26359
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:62510076-62576184 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 31.55 cM
Mapping Data

3 experiments

SNPs within 2kb

1469 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347090	protein coding gene	Chr8:62510076-62576227 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033638	protein coding gene	Chr8:62014566-62081071 (-)
A/J	MGP_AJ_G0033620	protein coding gene	Chr8:59367545-59428606 (-)
AKR/J	MGP_AKRJ_G0033545	protein coding gene	Chr8:61086057-61147696 (-)
BALB/cJ	MGP_BALBcJ_G0033616	protein coding gene	Chr8:59622468-59687360 (-)
C3H/HeJ	MGP_C3HHeJ_G0033326	protein coding gene	Chr8:61753827-61831042 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034133	protein coding gene	Chr8:64342506-64411708 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031081	protein coding gene	Chr8:54589805-54645738 (-)
CAST/EiJ	MGP_CASTEiJ_G0032651	protein coding gene	Chr8:61162096-61232409 (-)
CBA/J	MGP_CBAJ_G0033304	protein coding gene	Chr8:66711282-66781426 (-)
DBA/2J	MGP_DBA2J_G0033458	protein coding gene	Chr8:59114223-59186142 (-)
FVB/NJ	MGP_FVBNJ_G0033399	protein coding gene	Chr8:58420684-58483497 (-)
LP/J	MGP_LPJ_G0033546	protein coding gene	Chr8:61989440-62057316 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033443	protein coding gene	Chr8:68771762-68846852 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034151	protein coding gene	Chr8:61334912-61397081 (-)
PWK/PhJ	MGP_PWKPhJ_G0032360	protein coding gene	Chr8:58429006-58490525 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032196	protein coding gene	Chr8:60270621-60335090 (-)
WSB/EiJ	MGP_WSBEiJ_G0032768	protein coding gene	Chr8:61656461-61721198 (-)

Human Ortholog

ANXA10, annexin A10

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANXA10, annexin A10
Synonyms

ANX14
Links

HGNC:534

NCBI Gene ID: 11199

neXtProt AC: NX_Q9UJ72

UniProt: Q9UJ72
Chr Location

4q32.3; chr4:168092537-168187736 (+) GRCh38

MGI Vertebrate Homology

Anxa10 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ANXA10
Gene Tree

Anxa10

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

7
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Anxa10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Litter sizes from crosses of females that are either homozygous or heterozygous for a null allele contain fewer pups than wild-type females, indicating a dominant maternal effect on embryonic lethality. Embryos of homozygous null females die between E4.5 and E12.5.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANXA10

Xenbase anxa10

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All Sequences

43
RefSeq

4
UniProt

3
CCDS

CCDS52557.1, CCDS52558.1

Ensembl

ENSMUSG00000031635 (Evidence)
NCBI Gene

26359

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031635	Ensembl Gene Model \| MGI Sequence Detail	66109	C57BL/6J	± kb
transcript	ENSMUST00000034052	Ensembl \| MGI Sequence Detail	1763	Not Applicable
polypeptide	ENSMUSP00000034052	Ensembl \| MGI Sequence Detail	324	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004072 annexin A10

(term hierarchy)
InterPro Domains

IPR001464 Annexin

IPR008156 Annexin A10

IPR018502 Annexin repeat

IPR018252 Annexin repeat, conserved site

IPR037104 Annexin superfamily

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All nucleic 13

cDNA 13

Microarray probesets 4

Summaries

All 36

Gene Ontology 3

Phenotypes 13
Earliest

J:57244 Morgan RO, et al., Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. Genomics. 1999 Aug 15;60(1):40-9
Latest

J:357741 Park J, et al., SMYD5 methylation of rpL40 links ribosomal output to gastric cancer. Nature. 2024 Aug;632(8025):656-663

TSS for Anxa10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81407	Chr8:62576338-62576362 (-)	-166 bp
Tssr81406	Chr8:62576220-62576234 (-)	-43 bp
Tssr81405	Chr8:62576178-62576189 (-)	0 bp
Tssr81404	Chr8:62576163-62576172 (-)	16 bp
Tssr81403	Chr8:62576140-62576157 (-)	35 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24