Parg MGI Mouse Gene Detail - MGI:1347094 - poly (ADP-ribose) glycohydrolase

Symbol

Parg
Name

poly (ADP-ribose) glycohydrolase

Feature Type

protein coding gene
IDs

MGI:1347094
NCBI Gene: 26430
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:31923906-32019507 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.40 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

2243 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347094	protein coding gene	Chr14:31923900-32020671 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021142	protein coding gene	Chr14:25436313-25537454 (+)
A/J	MGP_AJ_G0021090	protein coding gene	Chr14:24467421-24563765 (+)
AKR/J	MGP_AKRJ_G0021067	protein coding gene	Chr14:25615348-25711132 (+)
BALB/cJ	MGP_BALBcJ_G0021094	protein coding gene	Chr14:24644267-24741146 (+)
C3H/HeJ	MGP_C3HHeJ_G0020877	protein coding gene	Chr14:25488842-25585592 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021526	protein coding gene	Chr14:26452698-26566122 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019089	protein coding gene	Chr14:24530744-24632519 (+)
CAST/EiJ	MGP_CASTEiJ_G0020402	protein coding gene	Chr14:25280876-25380449 (+)
CBA/J	MGP_CBAJ_G0020844	protein coding gene	Chr14:27439277-27544965 (+)
DBA/2J	MGP_DBA2J_G0020966	protein coding gene	Chr14:24498261-24596490 (+)
FVB/NJ	MGP_FVBNJ_G0020950	protein coding gene	Chr14:24462834-24558781 (+)
LP/J	MGP_LPJ_G0021035	protein coding gene	Chr14:25757765-25858644 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020976	protein coding gene	Chr14:26675425-26780514 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021559	protein coding gene	Chr14:25386363-25486455 (+)
PWK/PhJ	MGP_PWKPhJ_G0020150	protein coding gene	Chr14:23971036-24070597 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019974	protein coding gene	Chr14:24995683-25099035 (+)
WSB/EiJ	MGP_WSBEiJ_G0020457	protein coding gene	Chr14:25447937-25551189 (+)

Human Ortholog

PARG, poly(ADP-ribose) glycohydrolase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARG, poly(ADP-ribose) glycohydrolase
Synonyms

PARG99
Links

HGNC:8605

NCBI Gene ID: 8505

neXtProt AC: NX_Q86W56

UniProt: Q86W56
Chr Location

10q11.23; chr10:49818279-49970203 (-) GRCh38

MGI Vertebrate Homology

Parg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PARG
Gene Tree

Parg

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Phenotype Summary

14 phenotypes from 3 alleles in 4 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

3
Gene trapped

10
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one allele of this gene are hypersensitive to alkylating agents and ionizing radiation and susceptible to streptozotocin induced diabetes and endotoxic shock. Mice homozygous for a second allele display embryonic lethality and fail tohatch from the zona pellucida.

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All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

26
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parg

ZFIN parga

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All Sequences

77
RefSeq

14
UniProt

9
CCDS

CCDS36865.1

Ensembl

ENSMUSG00000021911 (Evidence)
NCBI Gene

26430

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021911	Ensembl Gene Model \| MGI Sequence Detail	95602	C57BL/6J	± kb
transcript	ENSMUST00000022470	Ensembl \| MGI Sequence Detail	4413	Not Applicable
polypeptide	ENSMUSP00000022470	Ensembl \| MGI Sequence Detail	961	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000012284 poly(ADP-ribose) glycohydrolase

(term hierarchy)
PDB

4FC2, 4N9Y, 4N9Z, 4NA0, 4NA4, 4NA5, 4NA6
EC

3.2.1.143
InterPro Domains

IPR007724 Poly(ADP-ribose) glycohydrolase

IPR048362 Poly (ADP-ribose) glycohydrolase, helical domain

IPR046372 Poly (ADP-ribose) glycohydrolase (PARG), catalytic domain
GlyGen

O88622 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 15

Microarray probesets 3

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MGI:2145628

Summaries

All 57

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 24
Earliest

J:57240 Ame JC, et al., Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization. Cytogenet Cell Genet. 1999;85(3-4):269-70
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Parg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124977	Chr14:31923894-31923952 (+)	17 bp
Tssr124978	Chr14:31923961-31923970 (+)	60 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24