Ceacam1 MGI Mouse Gene Detail - MGI:1347245 - CEA cell adhesion molecule 1

Symbol

Ceacam1
Name

CEA cell adhesion molecule 1
Synonyms

Bgp, Bgp1, Cc1, C-CAM, CD66a, Cea-1, Cea1, Cea-7, Cea7, Hv-2, Hv2, mCEA1, Mhv-1, MHVR1, mmCGM1, mmCGM2

Feature Type

protein coding gene
IDs

MGI:1347245
NCBI Gene: 26365
Member of

Cea cluster
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr7:25161132-25177028 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 13.84 cM
Mapping Data

10 experiments

SNPs within 2kb

597 from dbSNP Build 142
Strain Annotations

15
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347245	protein coding gene	Chr7:25161127-25177072 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031867	protein coding gene	Chr7:23943257-23961911 (-)
A/J	MGP_AJ_G0031847	protein coding gene	Chr7:23311295-23342658 (-)
AKR/J	MGP_AKRJ_G0031776	protein coding gene	Chr7:23888300-24018047 (-)
BALB/cJ	MGP_BALBcJ_G0031829	protein coding gene	Chr7:22869640-23638053 (-)
C3H/HeJ	MGP_C3HHeJ_G0031572	protein coding gene	Chr7:24300234-24363738 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032315	protein coding gene	Chr7:24751019-24830798 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029370	protein coding gene	Chr7:24730059-24745891 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0031537	protein coding gene	Chr7:25656625-25676147 (-)
DBA/2J	MGP_DBA2J_G0031691	protein coding gene	Chr7:23221854-23308836 (-)
FVB/NJ	MGP_FVBNJ_G0031644	protein coding gene	Chr7:23228753-23334149 (-)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0031682	protein coding gene	Chr7:25353620-25434341 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032347	protein coding gene	Chr7:23575706-23659996 (-)
PWK/PhJ	MGP_PWKPhJ_G0030636	protein coding gene	Chr7:18118769-18254827 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0031015	protein coding gene	Chr7:23762454-23805897 (-)

Human Ortholog

CEACAM1, CEA cell adhesion molecule 1

Vertebrate Orthologs

11

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEACAM1, CEA cell adhesion molecule 1
Synonyms

BGP, BGP1, BGPI
Links

HGNC:1814

NCBI Gene ID: 634

neXtProt AC: NX_P13688

UniProt: P13688
Chr Location

19q13.2; chr19:42507304-42561234 (-) GRCh38

Human Ortholog

CEACAM5, CEA cell adhesion molecule 5
Synonyms

CD66e, CEA
Links

HGNC:1817

NCBI Gene ID: 1048

neXtProt AC: NX_P06731

UniProt: P06731
Chr Location

19q13.2; chr19:41708585-41730433 (+) GRCh38

Human Ortholog

CEACAM6, CEA cell adhesion molecule 6
Synonyms

CD66c, CEAL, NCA, NCA-50/90
Links

HGNC:1818

NCBI Gene ID: 4680

neXtProt AC: NX_P40199

UniProt: P40199
Chr Location

19q13.2; chr19:41750977-41772211 (+) GRCh38

Human Ortholog

PSG1, pregnancy specific beta-1-glycoprotein 1
Synonyms

B1G1, CD66f, DHFRP2, FL-NCA-1/2, PBG1, PS-beta-C/D, PS-beta-G-1, PSBG-1, PSBG1, PSG95, PSGGA, PSGIIA, SP1
Links

HGNC:9514

NCBI Gene ID: 5669

neXtProt AC: NX_P11464

UniProt: P11464
Chr Location

19q13.2; chr19:42866464-42879822 (-) GRCh38

Human Ortholog

PSG3, pregnancy specific beta-1-glycoprotein 3
Links

HGNC:9520

NCBI Gene ID: 5671

neXtProt AC: NX_Q16557

UniProt: Q16557
Chr Location

19q13.2; chr19:42721638-42740481 (-) GRCh38

Human Ortholog

PSG4, pregnancy specific beta-1-glycoprotein 4
Synonyms

PSBG-4, PSBG-9, PSG9
Links

HGNC:9521

NCBI Gene ID: 5672

neXtProt AC: NX_Q00888

UniProt: Q00888
Chr Location

19q13.31; chr19:43192702-43207299 (-) GRCh38

Human Ortholog

PSG6, pregnancy specific beta-1-glycoprotein 6
Synonyms

PSBG-10, PSBG-12, PSBG-6, PSG10, PSGGB
Links

HGNC:9523

NCBI Gene ID: 5675

neXtProt AC: NX_Q00889

UniProt: Q00889
Chr Location

19q13.31; chr19:42902086-42919563 (-) GRCh38

Human Ortholog

PSG7, pregnancy specific beta-1-glycoprotein 7
Synonyms

PS-beta-G-7, PSBG-7, PSG1, PSGGA
Links

HGNC:9524

NCBI Gene ID: 5676

neXtProt AC: NX_Q13046

UniProt: Q13046
Chr Location

19q13.31; chr19:42924132-42937207 (-) GRCh38

Human Ortholog

PSG8, pregnancy specific beta-1-glycoprotein 8
Synonyms

PSG1
Links

HGNC:9525

NCBI Gene ID: 440533

neXtProt AC: NX_Q9UQ74

UniProt: Q9UQ74
Chr Location

19q13.2; chr19:42752686-42765678 (-) GRCh38

Human Ortholog

PSG9, pregnancy specific beta-1-glycoprotein 9
Synonyms

PS34, PSBG-11, PSBG-9, PSG11, PSGII
Links

HGNC:9526

NCBI Gene ID: 5678

neXtProt AC: NX_Q00887

UniProt: Q00887
Chr Location

19q13.31; chr19:43211791-43269530 (-) GRCh38

MGI Vertebrate Homology

Ceacam1 stringent orthology
10 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CEACAM1, CEACAM5, CEACAM6, PSG1, PSG3, PSG4, PSG6, PSG7, PSG8, PSG9
Gene Tree

Ceacam1

less

Phenotype Summary

15 phenotypes from 7 alleles in 7 genetic backgrounds
3 phenotypes from multigenic genotypes
69 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

3
Spontaneous

2
Targeted

10
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice lacking appreciable levels of the two isoforms containing 4 Ig domains and having increased levels of the two isoforms containing 2 Ig domains are viable and fertile. They are significantly more resistant to mouse hepatitis virus than wild-type mice.

less

All GO Annotations

172
GO References

39

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1224
Tissues

244
cDNA Data

30
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

82
RefSeq

10
UniProt

12
CCDS

CCDS20984.1, CCDS20985.1, CCDS39839.1, CCDS85244.1

Ensembl

ENSMUSG00000074272 (Evidence)
NCBI Gene

26365

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074272	Ensembl Gene Model \| MGI Sequence Detail	15897	C57BL/6J	± kb
transcript	ENSMUST00000098669	Ensembl \| MGI Sequence Detail	2873	Not Applicable
polypeptide	ENSMUSP00000096266	Ensembl \| MGI Sequence Detail	521	Not Applicable

less

UniProt

12 Sequences
Protein Ontology

PR:000001328 carcinoembryonic antigen-related cell adhesion molecule 1

(term hierarchy)
PDB

1L6Z, 3R4D, 5VST, 6VSJ
InterPro Domains

IPR050831 Carcinoembryonic antigen-related cell adhesion

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain
GlyGen

P31809 19 sites, 7 N-linked glycans (7 sites), 1 O-linked glycan (1 site)

less

All nucleic 48

Genomic 7

cDNA 32

Primer pair 3

Other 6

Microarray probesets 12

less

MGD-MRK-11017, MGD-MRK-11019, MGD-MRK-12228, MGD-MRK-1555, MGD-MRK-16442, MGD-MRK-1902, MGD-MRK-1908, MGD-MRK-1909, MGD-MRK-1915, MGI:88366, MGI:88372, MGI:96289, MGI:99657

Summaries

All 151

Developmental Gene Expression 13

Gene Ontology 39

Phenotypes 69
Earliest

J:6541 Knobler RL, et al., Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease. J Exp Med. 1981 Apr 1;153(4):832-43
Latest

J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984

TSS for Ceacam1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71267	Chr7:25177032-25177059 (-)	-18 bp
Tssr71266	Chr7:25177022-25177027 (-)	3 bp
Tssr71265	Chr7:25177007-25177019 (-)	15 bp
Tssr71264	Chr7:25176121-25176126 (-)	904 bp
Tssr71263	Chr7:25176067-25176079 (-)	955 bp
Tssr71262	Chr7:25175991-25176015 (-)	1,025 bp
Tssr71261	Chr7:25175977-25175988 (-)	1,045 bp
Tssr71260	Chr7:25175908-25175925 (-)	1,111 bp
Tssr71259	Chr7:25175831-25175851 (-)	1,187 bp
Tssr71258	Chr7:25171445-25171448 (-)	5,581 bp
Tssr71257	Chr7:25171398-25171422 (-)	5,618 bp
Tssr71256	Chr7:25171345-25171396 (-)	5,657 bp
Tssr71255	Chr7:25171247-25171253 (-)	5,778 bp
Tssr71254	Chr7:25165824-25165847 (-)	11,192 bp
Tssr71253	Chr7:25165782-25165808 (-)	11,233 bp
Tssr71252	Chr7:25165770-25165781 (-)	11,252 bp
Tssr71251	Chr7:25163690-25163693 (-)	13,336 bp
Tssr71250	Chr7:25163144-25163154 (-)	13,879 bp
Tssr71249	Chr7:25163125-25163143 (-)	13,894 bp
Tssr71248	Chr7:25162907-25162942 (-)	14,103 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24