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Ceacam2 Gene Detail
Summary
  • Symbol
    Ceacam2
  • Name
    CEA cell adhesion molecule 2
  • Synonyms
    Bgp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347246
    NCBI Gene: 26367
  • Member of
    Cea cluster
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25215467-25239282 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    682 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347246
 protein coding gene Chr7:25215467-25239429 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031868
 protein coding gene Chr7:24000607-24031272 (-)
A/J MGP_AJ_G0031846
 protein coding gene Chr7:23310489-23342661 (-)
AKR/J MGP_AKRJ_G0031775
 protein coding gene Chr7:23883340-23911885 (-)
BALB/cJ MGP_BALBcJ_G0031830
 protein coding gene Chr7:22869640-23638052 (-)
C3H/HeJ MGP_C3HHeJ_G0031573
 protein coding gene Chr7:24395601-24419797 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032316
 protein coding gene Chr7:24803138-24835535 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029371
 protein coding gene Chr7:24730059-24745891 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031538
 protein coding gene Chr7:25704277-25730582 (-)
DBA/2J MGP_DBA2J_G0031692
 protein coding gene Chr7:23280084-23308828 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031771
 protein coding gene Chr7:24239590-24255344 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0030637
 protein coding gene Chr7:18118853-18254826 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031016
 protein coding gene Chr7:23762454-23805897 (-)



Homology
more
  • Human Ortholog
    CEACAM1, CEA cell adhesion molecule 1
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEACAM1, CEA cell adhesion molecule 1
  • Synonyms
    BGP, BGP1, BGPI
  • Links
    NCBI Gene ID: 634
    neXtProt AC: NX_P13688
    UniProt: P13688

  • Chr Location
    19q13.2; chr19:42507304-42561234 (-)  GRCh38
  • Human Ortholog
    CEACAM5, CEA cell adhesion molecule 5
  • Synonyms
    CD66e, CEA
  • Links
    NCBI Gene ID: 1048
    neXtProt AC: NX_P06731
    UniProt: P06731

  • Chr Location
    19q13.2; chr19:41708585-41730433 (+)  GRCh38
  • Human Ortholog
    CEACAM6, CEA cell adhesion molecule 6
  • Synonyms
    CD66c, CEAL, NCA, NCA-50/90
  • Links
    NCBI Gene ID: 4680
    neXtProt AC: NX_P40199
    UniProt: P40199

  • Chr Location
    19q13.2; chr19:41750977-41772211 (+)  GRCh38
  • Human Ortholog
    PSG1, pregnancy specific beta-1-glycoprotein 1
  • Synonyms
    B1G1, CD66f, DHFRP2, FL-NCA-1/2, PBG1, PS-beta-C/D, PS-beta-G-1, PSBG-1, PSBG1, PSG95, PSGGA, PSGIIA, SP1
  • Links
    NCBI Gene ID: 5669
    neXtProt AC: NX_P11464
    UniProt: P11464

  • Chr Location
    19q13.2; chr19:42866464-42879822 (-)  GRCh38
  • Human Ortholog
    PSG3, pregnancy specific beta-1-glycoprotein 3
  • Links
    NCBI Gene ID: 5671
    neXtProt AC: NX_Q16557
    UniProt: Q16557

  • Chr Location
    19q13.2; chr19:42721638-42740481 (-)  GRCh38
  • Human Ortholog
    PSG4, pregnancy specific beta-1-glycoprotein 4
  • Synonyms
    PSBG-4, PSBG-9, PSG9
  • Links
    NCBI Gene ID: 5672
    neXtProt AC: NX_Q00888
    UniProt: Q00888

  • Chr Location
    19q13.31; chr19:43192702-43207299 (-)  GRCh38
  • Human Ortholog
    PSG6, pregnancy specific beta-1-glycoprotein 6
  • Synonyms
    PSBG-10, PSBG-12, PSBG-6, PSG10, PSGGB
  • Links
    NCBI Gene ID: 5675
    neXtProt AC: NX_Q00889
    UniProt: Q00889

  • Chr Location
    19q13.31; chr19:42902086-42919563 (-)  GRCh38
  • Human Ortholog
    PSG7, pregnancy specific beta-1-glycoprotein 7
  • Synonyms
    PS-beta-G-7, PSBG-7, PSG1, PSGGA
  • Links
    NCBI Gene ID: 5676
    neXtProt AC: NX_Q13046
    UniProt: Q13046

  • Chr Location
    19q13.31; chr19:42924132-42937207 (-)  GRCh38
  • Human Ortholog
    PSG8, pregnancy specific beta-1-glycoprotein 8
  • Synonyms
    PSG1
  • Links
    NCBI Gene ID: 440533
    neXtProt AC: NX_Q9UQ74
    UniProt: Q9UQ74

  • Chr Location
    19q13.2; chr19:42752686-42765678 (-)  GRCh38
  • Human Ortholog
    PSG9, pregnancy specific beta-1-glycoprotein 9
  • Synonyms
    PS34, PSBG-11, PSBG-9, PSG11, PSGII
  • Links
    NCBI Gene ID: 5678
    neXtProt AC: NX_Q00887
    UniProt: Q00887

  • Chr Location
    19q13.31; chr19:43211791-43269530 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female-specific obesity, disruption in glucose homeostasis, hyperphagia, hyperinsulinemia and decreased energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    20
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054385 Ensembl Gene Model | MGI Sequence Detail 23816 C57BL/6J ±  kb
    transcript ENSMUST00000044547 Ensembl | MGI Sequence Detail 2844 Not Applicable  
    polypeptide ENSMUSP00000048118 Ensembl | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 3
      cDNA 4
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16441, MGI:2141896, MGI:99656
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:18755 Nedellec P, et al., Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. J Virol. 1994 Jul;68(7):4525-37
    • Latest
      J:252718 Ghanem SS, et al., Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene. Diabetologia. 2017 Sep;60(9):1751-1760
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory