About   Help   FAQ
Slc27a4 Gene Detail
Summary
  • Symbol
    Slc27a4
  • Name
    solute carrier family 27 (fatty acid transporter), member 4
  • Synonyms
    FATP4, fatty acid transport protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347347
    NCBI Gene: 26569
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:29692646-29707534 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 20.64 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347347
 protein coding gene Chr2:29692646-29707534 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025544
 protein coding gene Chr2:27974431-27989125 (+)
A/J MGP_AJ_G0025522
 protein coding gene Chr2:26873892-26888580 (+)
AKR/J MGP_AKRJ_G0025491
 protein coding gene Chr2:27780077-27794552 (+)
BALB/cJ MGP_BALBcJ_G0025517
 protein coding gene Chr2:27005921-27020866 (+)
C3H/HeJ MGP_C3HHeJ_G0025279
 protein coding gene Chr2:27704155-27719755 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025962
 protein coding gene Chr2:28877938-28894971 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023371
 protein coding gene Chr2:25664049-25678540 (+)
CAST/EiJ MGP_CASTEiJ_G0024742
 protein coding gene Chr2:27596140-27612078 (+)
CBA/J MGP_CBAJ_G0025256
 protein coding gene Chr2:29878589-29896680 (+)
DBA/2J MGP_DBA2J_G0025389
 protein coding gene Chr2:26671090-26685998 (+)
FVB/NJ MGP_FVBNJ_G0025352
 protein coding gene Chr2:26473792-26488348 (+)
LP/J MGP_LPJ_G0025475
 protein coding gene Chr2:27893532-27908050 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025382
 protein coding gene Chr2:29806567-29821968 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026021
 protein coding gene Chr2:27694471-27715030 (+)
PWK/PhJ MGP_PWKPhJ_G0024488
 protein coding gene Chr2:26498688-26513564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024288
 protein coding gene Chr2:27780127-27795216 (+)
WSB/EiJ MGP_WSBEiJ_G0024810
 protein coding gene Chr2:27819083-27833725 (+)



Homology
more
  • Human Ortholog
    SLC27A4, solute carrier family 27 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC27A4, solute carrier family 27 member 4
  • Synonyms
    ACSVL4, FATP4, IPS
  • Links
    NCBI Gene ID: 10999
    neXtProt AC: NX_Q6P1M0
    UniProt: Q6P1M0

  • Chr Location
    9q34.11; chr9:128340527-128361470 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc27a4 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 6 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are not viable. While mice of one mutant line die during early development, mice of other mutant lines die at birth exhibiting abnormal skin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    115
  • cDNA Data
    74
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26569 NCBI Gene Model | MGI Sequence Detail 14889 C57BL/6J ±  kb
    transcript NM_011989 RefSeq | MGI Sequence Detail 4054 ZRU/MplStud  
    polypeptide Q91VE0 UniProt | EBI | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      Genomic 1
      cDNA 75
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139436
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 20
      Diseases 2
      Gene Ontology 24
      Phenotypes 32
    • Earliest
      J:42634 Hirsch D, et al., A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8625-9
    • Latest
      J:349093 Dearden L, et al., Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. PLoS Biol. 2024 Jun;22(6):e3002641
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory