Hunk MGI Mouse Gene Detail - MGI:1347352 - hormonally upregulated Neu-associated kinase

Symbol

Hunk
Name

hormonally upregulated Neu-associated kinase
Synonyms

Bstk1, Mak-v

Feature Type

protein coding gene
IDs

MGI:1347352
NCBI Gene: 26559
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr16:90182901-90296441 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 51.71 cM
Mapping Data

1 experiment

SNPs within 2kb

3828 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347352	protein coding gene	Chr16:90182550-90296443 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023026	protein coding gene	Chr16:91309564-91440831 (+)
A/J	MGP_AJ_G0022994	protein coding gene	Chr16:87059140-87174633 (+)
AKR/J	MGP_AKRJ_G0022964	protein coding gene	Chr16:89676308-89799787 (+)
BALB/cJ	MGP_BALBcJ_G0022996	protein coding gene	Chr16:87586749-87704488 (+)
C3H/HeJ	MGP_C3HHeJ_G0022757	protein coding gene	Chr16:90243085-90365883 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023443	protein coding gene	Chr16:94294028-94418248 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020945	protein coding gene	Chr16:84778260-84890180 (+)
CAST/EiJ	MGP_CASTEiJ_G0022276	protein coding gene	Chr16:90785339-90911176 (+)
CBA/J	MGP_CBAJ_G0022726	protein coding gene	Chr16:98283117-98421259 (+)
DBA/2J	MGP_DBA2J_G0022860	protein coding gene	Chr16:86960213-87078890 (+)
FVB/NJ	MGP_FVBNJ_G0022834	protein coding gene	Chr16:86093660-86210850 (+)
LP/J	MGP_LPJ_G0022930	protein coding gene	Chr16:91006241-91131715 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022855	protein coding gene	Chr16:102887825-103026435 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023461	protein coding gene	Chr16:90191704-90315907 (+)
PWK/PhJ	MGP_PWKPhJ_G0022021	protein coding gene	Chr16:87121725-87237283 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021851	protein coding gene	Chr16:89748170-89865671 (+)
WSB/EiJ	MGP_WSBEiJ_G0022328	protein coding gene	Chr16:90432392-90556719 (+)

Human Ortholog

HUNK, hormonally up-regulated Neu-associated kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HUNK, hormonally up-regulated Neu-associated kinase
Links

HGNC:13326

NCBI Gene ID: 30811

neXtProt AC: NX_P57058

UniProt: P57058
Chr Location

21q22.11; chr21:31873020-32044633 (+) GRCh38

MGI Vertebrate Homology

Hunk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HUNK
Gene Tree

Hunk

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References

4 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
82 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

2
Gene trapped

16
Spontaneous

1
Targeted

10
Genomic Mutations

8 involving Hunk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene result in no abnormal phenotype, however in combination with Tg(MMTV-Myc)Led mice, metastatic potential of mammary tumors is decreased.

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

88
cDNA Data

72
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hunk

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All Sequences

45
RefSeq

5
UniProt

4
CCDS

CCDS28315.1

Ensembl

ENSMUSG00000053414 (Evidence)
NCBI Gene

26559

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053414	Ensembl Gene Model \| MGI Sequence Detail	113541	C57BL/6J	± kb
transcript	ENSMUST00000065856	Ensembl \| MGI Sequence Detail	5393	Not Applicable
polypeptide	ENSMUSP00000068007	Ensembl \| MGI Sequence Detail	714	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008842 hormonally up-regulated neu tumor-associated kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR034671 Hormonally up-regulated neu tumour-associated kinase, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 75

cDNA 72

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 112

Developmental Gene Expression 6

Diseases 4

Gene Ontology 6

Phenotypes 82
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hunk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139286	Chr16:90182762-90182773 (+)	-133 bp
Tssr139287	Chr16:90182790-90182832 (+)	-90 bp
Tssr139288	Chr16:90182835-90182857 (+)	-55 bp
Tssr139289	Chr16:90182895-90182911 (+)	2 bp
Tssr139290	Chr16:90182913-90182940 (+)	26 bp
Tssr139291	Chr16:90183270-90183342 (+)	405 bp
Tssr139292	Chr16:90227399-90227422 (+)	44,510 bp
Tssr139293	Chr16:90294056-90294088 (+)	111,171 bp
Tssr139294	Chr16:90294092-90294101 (+)	111,196 bp
Tssr139295	Chr16:90295385-90295394 (+)	112,489 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24