Homer2 MGI Mouse Gene Detail - MGI:1347354 - homer scaffolding protein 2

Symbol

Homer2
Name

homer scaffolding protein 2
Synonyms

9330120H11Rik, CPD, Cupidin, Vesl-2

Feature Type

protein coding gene
IDs

MGI:1347354
NCBI Gene: 26557
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:81250229-81356673 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 45.71 cM
Mapping Data

2 experiments

SNPs within 2kb

3264 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347354	protein coding gene	Chr7:81250229-81357275 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032433	protein coding gene	Chr7:83670192-83787452 (-)
A/J	MGP_AJ_G0032412	protein coding gene	Chr7:81691595-81799649 (-)
AKR/J	MGP_AKRJ_G0032348	protein coding gene	Chr7:83499142-83618463 (-)
BALB/cJ	MGP_BALBcJ_G0032424	protein coding gene	Chr7:81350173-81460585 (-)
C3H/HeJ	MGP_C3HHeJ_G0032137	protein coding gene	Chr7:84113677-84227339 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032916	protein coding gene	Chr7:86950014-87059784 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029924	protein coding gene	Chr7:84172066-84276984 (-)
CAST/EiJ	MGP_CASTEiJ_G0031465	protein coding gene	Chr7:75051012-75154427 (-)
CBA/J	MGP_CBAJ_G0032103	protein coding gene	Chr7:89847910-89977247 (-)
DBA/2J	MGP_DBA2J_G0032258	protein coding gene	Chr7:80222887-80329579 (-)
FVB/NJ	MGP_FVBNJ_G0032213	protein coding gene	Chr7:80160967-80270766 (-)
LP/J	MGP_LPJ_G0032339	protein coding gene	Chr7:84901701-85018620 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032250	protein coding gene	Chr7:89911364-90033307 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032934	protein coding gene	Chr7:82907554-83028149 (-)
PWK/PhJ	MGP_PWKPhJ_G0031185	protein coding gene	Chr7:73436527-73546869 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031027	protein coding gene	Chr7:69930939-70038658 (-)
WSB/EiJ	MGP_WSBEiJ_G0031583	protein coding gene	Chr7:83281559-83391692 (-)

Human Ortholog

HOMER2, homer scaffold protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOMER2, homer scaffold protein 2
Synonyms

ACPD, CPD, DFNA68, HOMER-2, VESL-2
Links

HGNC:17513

NCBI Gene ID: 9455

neXtProt AC: NX_Q9NSB8

UniProt: Q9NSB8
Chr Location

15q25.2; chr15:82834661-82986157 (-) GRCh38

MGI Vertebrate Homology

Homer2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOMER2
Gene Tree

Homer2

Diseases

1 with human HOMER2 associations

				Human Disease	Mouse Models
				autosomal dominant nonsyndromic deafness 68 IDs autosomal dominant nonsyndromic deafness 68 DOID:0110589 ICD10CM:H90.3 OMIM:616707

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Homer2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit an increase in intracellular calcium concentration and in the frequency of intracellular calcium oscillations in pancreatic acinar cells.

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All GO Annotations

40
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1003
Tissues

123
cDNA Data

84
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOMER2

Xenbase homer2

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All Sequences

68
RefSeq

10
UniProt

7
CCDS

CCDS40009.1, CCDS52284.1, CCDS85329.1

Ensembl

ENSMUSG00000025813 (Evidence)
NCBI Gene

26557

			Length	Strain/Species	Flank
genomic	26557	NCBI Gene Model \| MGI Sequence Detail	106445	C57BL/6J	± kb
transcript	NM_011983	RefSeq \| MGI Sequence Detail	10999	C57BL/6
polypeptide	Q9QWW1	UniProt \| EBI \| MGI Sequence Detail	354	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000008679 homer protein homolog 2

(term hierarchy)
PDB

1I7A, 5ZZ9
InterPro Domains

IPR044100 Homer, EVH1 domain

IPR045027 Homer family

IPR011993 PH-like domain superfamily

IPR000697 WH1/EVH1 domain

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All nucleic 87

cDNA 84

Primer pair 3

Microarray probesets 6

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MGI:2142248, MGI:2442918

Summaries

All 70

Developmental Gene Expression 9

Gene Ontology 12

Phenotypes 30
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Homer2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73352	Chr7:81356830-81356846 (-)	-165 bp
Tssr73351	Chr7:81356653-81356712 (-)	-10 bp
Tssr73350	Chr7:81356638-81356649 (-)	29 bp
Tssr73349	Chr7:81356605-81356617 (-)	62 bp
Tssr73348	Chr7:81338225-81338230 (-)	18,445 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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