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Slc7a11 Gene Detail
Summary
  • Symbol
    Slc7a11
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
  • Synonyms
    9930009M05Rik, sut, System xc, xc, xCT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347355
    NCBI Gene: 26570
  • Alliance
    gene page
  • Transcription Start Sites
    75 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:50319385-50403947 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 21.72 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347355
 protein coding gene Chr3:49846975-50403947 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027192
 protein coding gene Chr3:48342629-48920586 (-)
A/J MGP_AJ_G0027152
 protein coding gene Chr3:46924313-47511789 (-)
AKR/J MGP_AKRJ_G0027121
 protein coding gene Chr3:47872596-48459717 (-)
BALB/cJ MGP_BALBcJ_G0027164
 protein coding gene Chr3:46819247-47380990 (-)
C3H/HeJ MGP_C3HHeJ_G0026907
 protein coding gene Chr3:48085362-48653906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027610
 protein coding gene Chr3:50308481-50887298 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024970
 protein coding gene Chr3:43647845-44180734 (-)
CAST/EiJ MGP_CASTEiJ_G0026360
 protein coding gene Chr3:48135455-48722041 (-)
CBA/J MGP_CBAJ_G0026884
 protein coding gene Chr3:51868590-52491670 (-)
DBA/2J MGP_DBA2J_G0027018
 protein coding gene Chr3:46568022-47132825 (-)
FVB/NJ MGP_FVBNJ_G0026986
 protein coding gene Chr3:45577075-46126559 (-)
LP/J MGP_LPJ_G0027130
 protein coding gene Chr3:49102243-49666973 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027004
 protein coding gene Chr3:56090875-56721958 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027669
 protein coding gene Chr3:47806957-48370142 (-)
PWK/PhJ MGP_PWKPhJ_G0026092
 protein coding gene Chr3:46178405-46742251 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025905
 protein coding gene Chr3:47418189-48005541 (-)
WSB/EiJ MGP_WSBEiJ_G0026434
 protein coding gene Chr3:47901441-48467719 (-)



Homology
more
  • Human Ortholog
    SLC7A11, solute carrier family 7 member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A11, solute carrier family 7 member 11
  • Synonyms
    CCBR1, xCT
  • Links
    NCBI Gene ID: 23657
    neXtProt AC: NX_Q9UPY5
    UniProt: Q9UPY5

  • Chr Location
    4q28.3; chr4:138164097-138312671 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Slc7a11 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show a reduction in yellow pigment resulting in dilution of agouti; only pinna hairs are affected in nonagouti mice. Mice homozygous for an ENU-induced allele exhibit decreased survival of LPS-induced macrophages and increased incidence of chemically-induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    63
  • cDNA Data
    23
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26570 NCBI Gene Model | MGI Sequence Detail 84563 C57BL/6J ±  kb
    transcript NM_011990 RefSeq | MGI Sequence Detail 9227 Not Specified  
    polypeptide Q9WTR6 UniProt | EBI | MGI Sequence Detail 502 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14656, MGI:2139719, MGI:2442155, MGI:98448
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 19
      Phenotypes 65
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:352020 Yang B, et al., Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice. Int J Biol Sci. 2024;20(7):2555-2575
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory