Foxa3 MGI Mouse Gene Detail - MGI:1347477

Symbol

Foxa3
Name

forkhead box A3
Synonyms

Hnf-3g, Hnf3g, Tcf-3g, Tcf3g

Feature Type

protein coding gene
IDs

MGI:1347477
NCBI Gene: 15377
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:18747209-18757463 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.46 cM
Mapping Data

4 experiments

SNPs within 2kb

328 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347477	protein coding gene	Chr7:18747208-18757464 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031753	protein coding gene	Chr7:16955020-16968384 (-)
A/J	MGP_AJ_G0031729	protein coding gene	Chr7:16652539-16663748 (-)
AKR/J	MGP_AKRJ_G0031655	protein coding gene	Chr7:17110384-17120139 (-)
BALB/cJ	MGP_BALBcJ_G0031734	protein coding gene	Chr7:16845135-16855448 (-)
C3H/HeJ	MGP_C3HHeJ_G0031456	protein coding gene	Chr7:17361487-17373490 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032200	protein coding gene	Chr7:17844270-17855071 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029266	protein coding gene	Chr7:18299035-18309040 (-)
CAST/EiJ	MGP_CASTEiJ_G0030799	protein coding gene	Chr7:13765622-13775864 (-)
CBA/J	MGP_CBAJ_G0031418	protein coding gene	Chr7:18492316-18505375 (-)
DBA/2J	MGP_DBA2J_G0031573	protein coding gene	Chr7:16586366-16596988 (-)
FVB/NJ	MGP_FVBNJ_G0031525	protein coding gene	Chr7:16447346-16459753 (-)
LP/J	MGP_LPJ_G0031656	protein coding gene	Chr7:17297481-17312298 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031561	protein coding gene	Chr7:18350447-18364150 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032228	protein coding gene	Chr7:16709495-16720245 (-)
PWK/PhJ	MGP_PWKPhJ_G0030523	protein coding gene	Chr7:13670930-13681312 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030350	protein coding gene	Chr7:11398704-11408421 (-)
WSB/EiJ	MGP_WSBEiJ_G0030899	protein coding gene	Chr7:16913805-16923722 (-)

Human Ortholog

FOXA3, forkhead box A3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXA3, forkhead box A3
Synonyms

FKHH3, HNF3G, TCF3G
Links

HGNC:5023

NCBI Gene ID: 3171

neXtProt AC: NX_P55318

UniProt: P55318
Chr Location

19q13.32; chr19:45863989-45873797 (+) GRCh38

MGI Vertebrate Homology

Foxa3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FOXA3
Gene Tree

Foxa3

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Phenotype Summary

23 phenotypes from 1 allele in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

2
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit reduced expression of several liver-specific and liver-enriched genes. Homozygous mice exhibit abnormal glucose homeostasis and reduced male fertility with abnormal spermatogeneis. Mice remodel their fat tissues on high fat diets, store less fat, and burn more energy as they age. Mutant mice live significantly longer than controls.

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All GO Annotations

35
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

928
Tissues

170
cDNA Data

22
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN foxa3

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS20886.1

Ensembl

ENSMUSG00000040891 (Evidence)
NCBI Gene

15377

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040891	Ensembl Gene Model \| MGI Sequence Detail	10255	C57BL/6J	± kb
transcript	ENSMUST00000036018	Ensembl \| MGI Sequence Detail	2037	Not Applicable
polypeptide	ENSMUSP00000043173	Ensembl \| MGI Sequence Detail	353	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007604 hepatocyte nuclear factor 3-gamma

(term hierarchy)
InterPro Domains

IPR050211 Forkhead box domain-containing protein

IPR001766 Fork head domain

IPR018122 Fork head domain conserved site1

IPR030456 Fork head domain conserved site 2

IPR013638 Fork-head N-terminal

IPR047366 Hepatocyte nuclear factor 3-gamma, forkhead domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 35

Genomic 5

cDNA 24

Primer pair 5

Other 1

Microarray probesets 3

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MGD-MRK-10806, MGD-MRK-14751, MGD-MRK-14757, MGD-MRK-16683, MGI:99888

Summaries

All 94

Developmental Gene Expression 34

Gene Ontology 13

Phenotypes 17
Earliest

J:17361 Flower DR, et al., Mouse oncogene protein 24p3 is a member of the lipocalin protein family. Biochem Biophys Res Commun. 1991 Oct 15;180(1):69-74
Latest

J:324296 Bell N, et al., Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes. Bone. 2022 Apr 6;160:116418

TSS for Foxa3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70866	Chr7:18757467-18757471 (-)	-6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24