Foxf2 MGI Mouse Gene Detail - MGI:1347479

Symbol

Foxf2
Name

forkhead box F2
Synonyms

Fkh20, FREAC2, LUN

Feature Type

protein coding gene
IDs

MGI:1347479
NCBI Gene: 14238
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:31809799-31815386 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.48 cM, cytoband A4
Mapping Data

1 experiment

SNPs within 2kb

154 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347479	protein coding gene	Chr13:31809686-31815390 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020422	protein coding gene	Chr13:29555269-29560852 (+)
A/J	MGP_AJ_G0020377	protein coding gene	Chr13:28757343-28762936 (+)
AKR/J	MGP_AKRJ_G0020354	protein coding gene	Chr13:29384819-29390408 (+)
BALB/cJ	MGP_BALBcJ_G0020372	protein coding gene	Chr13:28856375-28861970 (+)
C3H/HeJ	MGP_C3HHeJ_G0020175	protein coding gene	Chr13:29390457-29396048 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020808	protein coding gene	Chr13:30558744-30564333 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018399	protein coding gene	Chr13:27134023-27139514 (+)
CAST/EiJ	MGP_CASTEiJ_G0019692	protein coding gene	Chr13:29076953-29082545 (+)
CBA/J	MGP_CBAJ_G0020131	protein coding gene	Chr13:31858725-31864318 (+)
DBA/2J	MGP_DBA2J_G0020253	protein coding gene	Chr13:28283927-28289518 (+)
FVB/NJ	MGP_FVBNJ_G0020238	protein coding gene	Chr13:27895509-27901098 (+)
LP/J	MGP_LPJ_G0020330	protein coding gene	Chr13:29772318-29777909 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020264	protein coding gene	Chr13:31948783-31954364 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020849	protein coding gene	Chr13:29043256-29048849 (+)
PWK/PhJ	MGP_PWKPhJ_G0019447	protein coding gene	Chr13:28443821-28449665 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019268	protein coding gene	Chr13:27938883-27944506 (+)
WSB/EiJ	MGP_WSBEiJ_G0019754	protein coding gene	Chr13:29346139-29351968 (+)

Human Ortholog

FOXF2, forkhead box F2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXF2, forkhead box F2
Synonyms

FKHL6, FREAC-2, FREAC2
Links

HGNC:3810

NCBI Gene ID: 2295

neXtProt AC: NX_Q12947

UniProt: Q12947
Chr Location

6p25.3; chr6:1389576-1395603 (+) GRCh38

MGI Vertebrate Homology

Foxf2 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: FOXF2
Gene Tree

Foxf2

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Phenotype Summary

37 phenotypes from 2 alleles in 2 genetic backgrounds
5 images
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

10
Genomic Mutations

2 involving Foxf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice do not live through the first day of life due to an inability to suckle, which is secondary to cleft palate and tongue abnormalities. Mice homozygous for an ENU mutation exhibit postnatal lethality without palate defect and abnormal anterior segment dysgenesis.

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All GO Annotations

42
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1070
Tissues

232
cDNA Data

15
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase foxf2

ZFIN foxf2a, foxf2b

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS26424.1

Ensembl

ENSMUSG00000038402 (Evidence)
NCBI Gene

14238

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038402	Ensembl Gene Model \| MGI Sequence Detail	5588	C57BL/6J	± kb
transcript	ENSMUST00000042054	Ensembl \| MGI Sequence Detail	2363	Not Applicable
polypeptide	ENSMUSP00000046789	Ensembl \| MGI Sequence Detail	446	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007622 forkhead box protein F2

(term hierarchy)
InterPro Domains

IPR051770 Forkhead box transcription regulator

IPR001766 Fork head domain

IPR018122 Fork head domain conserved site1

IPR030456 Fork head domain conserved site 2

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 22

Genomic 1

cDNA 15

Primer pair 5

Other 1

Microarray probesets 3

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MGI:1298400

Summaries

All 87

Developmental Gene Expression 45

Gene Ontology 9

Phenotypes 28
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)

TSS for Foxf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119127	Chr13:31809662-31809710 (+)	-113 bp
Tssr119128	Chr13:31809711-31809727 (+)	-80 bp
Tssr119129	Chr13:31809728-31809742 (+)	-64 bp
Tssr119130	Chr13:31809776-31809783 (+)	-19 bp
Tssr119131	Chr13:31809785-31809796 (+)	-8 bp
Tssr119132	Chr13:31809889-31809902 (+)	97 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24