Foxk1 MGI Mouse Gene Detail - MGI:1347488

Symbol

Foxk1
Name

forkhead box K1
Synonyms

A630048H08Rik, Mnf

Feature Type

protein coding gene
IDs

MGI:1347488
NCBI Gene: 17425
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:142387252-142447766 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 81.53 cM
Mapping Data

7 experiments

SNPs within 2kb

1610 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347488	protein coding gene	Chr5:142387252-142447770 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030310	protein coding gene	Chr5:147627153-147691920 (+)
A/J	MGP_AJ_G0030279	protein coding gene	Chr5:141313619-141376562 (+)
AKR/J	MGP_AKRJ_G0030211	protein coding gene	Chr5:145722461-145785084 (+)
BALB/cJ	MGP_BALBcJ_G0030296	protein coding gene	Chr5:142561190-142622669 (+)
C3H/HeJ	MGP_C3HHeJ_G0030007	protein coding gene	Chr5:146543814-146608510 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030741	protein coding gene	Chr5:153042446-153109075 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027959	protein coding gene	Chr5:135128726-135192555 (+)
CAST/EiJ	MGP_CASTEiJ_G0029412	protein coding gene	Chr5:145991691-146058835 (+)
CBA/J	MGP_CBAJ_G0029977	protein coding gene	Chr5:159287083-159358307 (+)
DBA/2J	MGP_DBA2J_G0030127	protein coding gene	Chr5:141091597-141152722 (+)
FVB/NJ	MGP_FVBNJ_G0030082	protein coding gene	Chr5:140280660-140341977 (+)
LP/J	MGP_LPJ_G0030213	protein coding gene	Chr5:148251370-148314377 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030113	protein coding gene	Chr5:161815259-161877633 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030781	protein coding gene	Chr5:145577850-145638919 (+)
PWK/PhJ	MGP_PWKPhJ_G0029127	protein coding gene	Chr5:140155825-140218330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028963	protein coding gene	Chr5:143304354-143375590 (+)
WSB/EiJ	MGP_WSBEiJ_G0029486	protein coding gene	Chr5:146366964-146432758 (+)

Human Ortholog

FOXK1, forkhead box K1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXK1, forkhead box K1
Synonyms

FOXK1L
Links

HGNC:23480

NCBI Gene ID: 221937

neXtProt AC: NX_P85037

UniProt: P85037
Chr Location

7p22.1; chr7:4682295-4771442 (+) GRCh38

MGI Vertebrate Homology

Foxk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FOXK1
Gene Tree

Foxk1

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

6
Gene trapped

20
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are runted and exhibit a reduced myogenic progenitor cell population with impaired cell cycle progression (G0/G1 arrest) and decreased proliferative capacity that results in severe impairment of skeletal muscle regeneration following injury.

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All GO Annotations

37
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

904
Tissues

137
cDNA Data

17
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FOXK1

ZFIN foxk1

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All Sequences

47
RefSeq

4
UniProt

3
CCDS

CCDS19826.1

Ensembl

ENSMUSG00000056493 (Evidence)
NCBI Gene

17425

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056493	Ensembl Gene Model \| MGI Sequence Detail	60515	C57BL/6J	± kb
transcript	ENSMUST00000072837	Ensembl \| MGI Sequence Detail	7439	Not Applicable
polypeptide	ENSMUSP00000072616	Ensembl \| MGI Sequence Detail	719	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007631 forkhead box protein K1

(term hierarchy)
PDB

2A3S, 2D2W
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR047394 Forkhead box protein K1, forkhead domain

IPR001766 Fork head domain

IPR018122 Fork head domain conserved site1

IPR030456 Fork head domain conserved site 2

IPR008984 SMAD/FHA domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

P42128 8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (7 sites)

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All nucleic 26

cDNA 18

Primer pair 6

Other 2

Microarray probesets 6

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MGD-MRK-12338, MGI:2140907, MGI:97042

Summaries

All 68

Developmental Gene Expression 19

Diseases 1

Gene Ontology 10

Phenotypes 11
Earliest

J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
Latest

J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180

TSS for Foxk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49576	Chr5:142387239-142387287 (+)	11 bp
Tssr49577	Chr5:142426861-142426865 (+)	39,611 bp
Tssr49578	Chr5:142439713-142439746 (+)	52,478 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24