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Pla2g10 Gene Detail
Summary
  • Symbol
    Pla2g10
  • Name
    phospholipase A2, group X
  • Synonyms
    GX sPLA2, mGXsPLA2, PLA2GX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347522
    NCBI Gene: 26565
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13532921-13548847 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    515 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347522
 protein coding gene Chr16:13532921-13548863 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022534
 protein coding gene Chr16:10695292-10714217 (-)
A/J MGP_AJ_G0022496
 protein coding gene Chr16:10114827-10131086 (-)
AKR/J MGP_AKRJ_G0022472
 protein coding gene Chr16:10550986-10569264 (-)
BALB/cJ MGP_BALBcJ_G0022500
 protein coding gene Chr16:10281889-10297969 (-)
C3H/HeJ MGP_C3HHeJ_G0022267
 protein coding gene Chr16:10646946-10667153 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022949
 protein coding gene Chr16:10863799-10882018 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020469
 protein coding gene Chr16:10207234-10221656 (-)
CAST/EiJ MGP_CASTEiJ_G0021794
 protein coding gene Chr16:10650627-10667458 (-)
CBA/J MGP_CBAJ_G0022236
 protein coding gene Chr16:11363714-11390737 (-)
DBA/2J MGP_DBA2J_G0022367
 protein coding gene Chr16:10111826-10128941 (-)
FVB/NJ MGP_FVBNJ_G0022343
 protein coding gene Chr16:10095783-10111176 (-)
LP/J MGP_LPJ_G0022435
 protein coding gene Chr16:10613348-10629170 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022365
 protein coding gene Chr16:11007695-11030047 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022962
 protein coding gene Chr16:10529424-10546779 (-)
PWK/PhJ MGP_PWKPhJ_G0021536
 protein coding gene Chr16:10371163-10388037 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021364
 protein coding gene Chr16:10520721-10536437 (-)
WSB/EiJ MGP_WSBEiJ_G0021842
 protein coding gene Chr16:10541808-10557705 (-)



Homology
more
  • Human Ortholog
    PLA2G10, phospholipase A2 group X
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G10, phospholipase A2 group X
  • Synonyms
    GXPLA2, GXSPLA2, SPLA2, sPLA2-X
  • Links
    NCBI Gene ID: 8399
    neXtProt AC: NX_O15496
    UniProt: O15496

  • Chr Location
    16p13.12-p13.11; chr16:14672548-14701850 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 6 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    102
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022683 Ensembl Gene Model | MGI Sequence Detail 15927 C57BL/6J ±  kb
    transcript ENSMUST00000023364 Ensembl | MGI Sequence Detail 1423 Not Applicable  
    polypeptide ENSMUSP00000023364 Ensembl | MGI Sequence Detail 151 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 33
    • Earliest
      J:41210 Cupillard L, et al., Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. J Biol Chem. 1997 Jun 20;272(25):15745-52
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory