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Sdc4 Gene Detail
Summary
  • Symbol
    Sdc4
  • Name
    syndecan 4
  • Synonyms
    ryudocan, S4, Synd4, syndecan-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349164
    NCBI Gene: 20971
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164266167-164285512 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349164
 protein coding gene Chr2:164266167-164285807 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026851
 protein coding gene Chr2:169865997-169885667 (-)
A/J MGP_AJ_G0026817
 protein coding gene Chr2:162951976-162971662 (-)
AKR/J MGP_AKRJ_G0026788
 protein coding gene Chr2:167793153-167812778 (-)
BALB/cJ MGP_BALBcJ_G0026826
 protein coding gene Chr2:163314284-163333870 (-)
C3H/HeJ MGP_C3HHeJ_G0026568
 protein coding gene Chr2:168148233-168167856 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027274
 protein coding gene Chr2:174778719-174801276 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024644
 protein coding gene Chr2:156363191-156382749 (-)
CAST/EiJ MGP_CASTEiJ_G0026028
 protein coding gene Chr2:168569525-168589371 (-)
CBA/J MGP_CBAJ_G0026545
 protein coding gene Chr2:181125312-181145236 (-)
DBA/2J MGP_DBA2J_G0026683
 protein coding gene Chr2:162122946-162142566 (-)
FVB/NJ MGP_FVBNJ_G0026649
 protein coding gene Chr2:160535683-160556226 (-)
LP/J MGP_LPJ_G0026786
 protein coding gene Chr2:169948438-169968086 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026669
 protein coding gene Chr2:184720957-184742794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027330
 protein coding gene Chr2:167695607-167716050 (-)
PWK/PhJ MGP_PWKPhJ_G0025763
 protein coding gene Chr2:161699736-161719532 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025564
 protein coding gene Chr2:166567010-166587502 (-)
WSB/EiJ MGP_WSBEiJ_G0026099
 protein coding gene Chr2:168553354-168574956 (-)



Homology
more
  • Human Ortholog
    SDC4, syndecan 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDC4, syndecan 4
  • Synonyms
    SYND4
  • Links
    NCBI Gene ID: 6385
    neXtProt AC: NX_P31431
    UniProt: P31431

  • Chr Location
    20q13.12; chr20:45325288-45348424 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a knock-out allele show delayed wound healing and impaired angiogenesis. Homozygotes for a different knock-out allele exhibit degenerated fetal vessels in the placental labyrinth, abnormal cell adhesion, and high susceptibility to induced renal and hepatic injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1096
  • Tissues
    153
  • cDNA Data
    188
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20971 NCBI Gene Model | MGI Sequence Detail 19346 C57BL/6J ±  kb
    transcript NM_011521 RefSeq | MGI Sequence Detail 2460 ZRU/MplStud  
    polypeptide O35988 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 194
      cDNA 188
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14689, MGI:2138809, MGI:2139303, MGI:98466
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 27
      Gene Ontology 10
      Phenotypes 71
    • Earliest
      J:23985 Baciu PC, et al., Prediction of a novel integral membrane proteoglycan core protein related to Syndecan and Fibroglycan. J Cell Biol. 1991;115:125a
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory