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Sdc2 Gene Detail
Summary
  • Symbol
    Sdc2
  • Name
    syndecan 2
  • Synonyms
    4833414L08Rik, fibroglycan, Hspg1, Synd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349165
    NCBI Gene: 15529
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:32920869-33034867 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 13.74 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3640 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349165
 protein coding gene Chr15:32920869-33035081 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021772
 protein coding gene Chr15:31221761-31337947 (+)
A/J MGP_AJ_G0021733
 protein coding gene Chr15:29974919-30089002 (+)
AKR/J MGP_AKRJ_G0021710
 protein coding gene Chr15:30745692-30865919 (+)
BALB/cJ MGP_BALBcJ_G0021739
 protein coding gene Chr15:29852675-30094321 (+)
C3H/HeJ MGP_C3HHeJ_G0021514
 protein coding gene Chr15:30634891-30910679 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022178
 protein coding gene Chr15:32403518-32540070 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019716
 protein coding gene Chr15:27971509-28072639 (+)
CAST/EiJ MGP_CASTEiJ_G0021030
 protein coding gene Chr15:31129463-31350964 (+)
CBA/J MGP_CBAJ_G0021483
 protein coding gene Chr15:33202200-33472807 (+)
DBA/2J MGP_DBA2J_G0021607
 protein coding gene Chr15:29779013-29895161 (+)
FVB/NJ MGP_FVBNJ_G0021585
 protein coding gene Chr15:29143811-29391699 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0021610
 protein coding gene Chr15:36446529-36466285 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022201
 protein coding gene Chr15:30844305-31117226 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021086
 protein coding gene Chr15:30831190-31086230 (+)



Homology
more
  • Human Ortholog
    SDC2, syndecan 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDC2, syndecan 2
  • Synonyms
    CD362, HSPG, HSPG1, SYND2
  • Links
    NCBI Gene ID: 6383
    neXtProt AC: NX_P34741
    UniProt: P34741

  • Chr Location
    8q22.1; chr8:96493813-96611790 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SDC2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced angiogenesis and VEGFA165-induced endothelial cell proliferation and migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    88
  • cDNA Data
    135
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15529 NCBI Gene Model | MGI Sequence Detail 113999 C57BL/6J ±  kb
    transcript NM_008304 RefSeq | MGI Sequence Detail 3313 ZRU/MplStud  
    polypeptide P43407 UniProt | EBI | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      cDNA 135
      Primer pair 5
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10975, MGD-MRK-14687, MGI:1921849, MGI:2145934, MGI:96256
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 28
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory