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Ccl21b Gene Detail
Summary
  • Symbol
    Ccl21b
  • Name
    C-C motif chemokine ligand 21B (leucine)
  • Synonyms
    6CKBAC1, 6Ckine, CKb9, Exodus-2, Scya21, Scya21a, SLC, TCA4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349182
    NCBI Gene: 100042493
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:42255693-42256825 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.12 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349182
 protein coding gene Chr4:42173120-42256825 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028191
 protein coding gene Chr4:40819864-40820529 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0028167
 protein coding gene Chr4:39460192-39460857 (-)
C3H/HeJ MGP_C3HHeJ_G0027889
 protein coding gene Chr4:40881226-40881891 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0027971
 protein coding gene Chr4:38539776-38540441 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027995
 protein coding gene Chr4:46960941-46961605 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026881
 protein coding gene Chr4:40004776-40005441 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CCL21, C-C motif chemokine ligand 21
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL21, C-C motif chemokine ligand 21
  • Synonyms
    6Ckine, CKb9, ECL, SCYA21, SLC, TCA4
  • Links
    NCBI Gene ID: 6366
    neXtProt AC: NX_O00585
    UniProt: O00585

  • Chr Location
    9p13.3; chr9:34709005-34710136 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    25
  • cDNA Data
    4
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000095675 Ensembl Gene Model | MGI Sequence Detail 1133 C57BL/6J ±  kb
    transcript ENSMUST00000178864 Ensembl | MGI Sequence Detail 869 Not Applicable  
    polypeptide ENSMUSP00000137149 Ensembl | MGI Sequence Detail 133 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 8
      cDNA 5
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1097677, MGI:2140200
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 16
      Gene Ontology 7
      Phenotypes 4
    • Earliest
      J:42623 Hromas R, et al., Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J Immunol. 1997 Sep 15;159(6):2554-8
    • Latest
      J:279965 Gonzalez Badillo FE, et al., CCL21 Expression in beta-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice. Diabetes. 2019 Oct;68(10):1990-2003
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory