Cops7b Gene Detail

Summary

• Symbol
  Cops7b
• Name
  COP9 signalosome subunit 7B
• Synonyms
  COP9 complex S7b, D1Wsu66e

• Feature Type
  protein coding gene
• IDs
  MGI:1349388
  NCBI Gene: 26895
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr1:86510363-86534550 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 43.97 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  554 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349388	protein coding gene	Chr1:86510363-86537097 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016251	protein coding gene	Chr1:87873370-87907219 (+)
A/J	MGP_AJ_G0016232	protein coding gene	Chr1:84602218-84629796 (+)
AKR/J	MGP_AKRJ_G0016193	protein coding gene	Chr1:87080797-87107212 (+)
BALB/cJ	MGP_BALBcJ_G0016189	protein coding gene	Chr1:84717780-84744939 (+)
C3H/HeJ	MGP_C3HHeJ_G0016017	protein coding gene	Chr1:87323590-87356241 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016645	protein coding gene	Chr1:91206345-91234060 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014367	protein coding gene	Chr1:79085596-79113954 (+)
CAST/EiJ	MGP_CASTEiJ_G0015602	protein coding gene	Chr1:86555241-86581102 (+)
CBA/J	MGP_CBAJ_G0015993	protein coding gene	Chr1:94048546-94077031 (+)
DBA/2J	MGP_DBA2J_G0016096	protein coding gene	Chr1:83911419-83938334 (+)
FVB/NJ	MGP_FVBNJ_G0016095	protein coding gene	Chr1:82965772-82992595 (+)
LP/J	MGP_LPJ_G0016167	protein coding gene	Chr1:88962962-88995553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016121	protein coding gene	Chr1:97297219-97324556 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016688	protein coding gene	Chr1:87203969-87234176 (+)
PWK/PhJ	MGP_PWKPhJ_G0015389	protein coding gene	Chr1:83196964-83225445 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015169	protein coding gene	Chr1:86148973-86176960 (+)
WSB/EiJ	MGP_WSBEiJ_G0015666	protein coding gene	Chr1:86845649-86873330 (+)

Homology

• Human Ortholog
  COPS7B, COP9 signalosome subunit 7B

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  COPS7B, COP9 signalosome subunit 7B
  
• Synonyms
  CSN7B, SGN7b
• Links
  HGNC:16760

  NCBI Gene ID: 64708

  neXtProt AC: NX_Q9H9Q2

  UniProt: Q9H9Q2

  
  
• Chr Location
  2q37.1; chr2:231781671-231809254 (+)  GRCh38

---

• MGI Vertebrate Homology
  Cops7b stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: COPS7B
• Gene Tree
  Cops7b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotype references
  

• All Mutations and Alleles
  12
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Gene trapped
  5
• Radiation induced
  1
• Targeted
  3
• Genomic Mutations
  2 involving Cops7b
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  19 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  9
• GO References
  5

Expression

• Assay Results
  836
• Tissues
  45
• cDNA Data
  63
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase cops7b

Sequences &
Gene Models

• All Sequences
  67
• RefSeq
  12
• UniProt
  5
• CCDS
  CCDS15122.1

• Ensembl
  ENSMUSG00000026240 (Evidence)
• NCBI Gene
  26895

Representative Sequences			Length	Strain/Species
genomic	26895	NCBI Gene Model | MGI Sequence Detail	24188	C57BL/6J
transcript	NM_172974	RefSeq | MGI Sequence Detail	2819	ZRU/MplStud
polypeptide	Q8BV13	UniProt | EBI | MGI Sequence Detail	264	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000005745 COP9 signalosome complex subunit 7b
  (term hierarchy)
• InterPro Domains
  IPR041481 COP9 signalosome complex subunit 7, helix I
  IPR045237 Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7
  IPR000717 Proteasome component (PCI) domain
• GlyGen
  Q8BV13 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 64

  cDNA 63

  Primer pair 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-34265, MGI:106571

References

• Summaries
  All 39

  Developmental Gene Expression 3

  Gene Ontology 5

  Phenotypes 11
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Cops7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7773	Chr1:86510615-86510652 (+)	271 bp
Tssr7774	Chr1:86514847-86514878 (+)	4,500 bp