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Map4k4 Gene Detail
Summary
  • Symbol
    Map4k4
  • Name
    mitogen-activated protein kinase kinase kinase kinase 4
  • Synonyms
    9430080K19Rik, Nik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349394
    NCBI Gene: 26921
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:39940073-40065470 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 18.53 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3830 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349394
protein coding gene Chr1:39939806-40065470 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015963
protein coding gene Chr1:38670239-38805652 (+)
A/J MGP_AJ_G0015947
protein coding gene Chr1:37577624-37705815 (+)
AKR/J MGP_AKRJ_G0015902
protein coding gene Chr1:38077173-38201530 (+)
BALB/cJ MGP_BALBcJ_G0015901
protein coding gene Chr1:37230785-37364259 (+)
C3H/HeJ MGP_C3HHeJ_G0015734
protein coding gene Chr1:38352097-38481390 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016354
protein coding gene Chr1:40267371-40400663 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014076
protein coding gene Chr1:34532666-34657413 (+)
CAST/EiJ MGP_CASTEiJ_G0015315
protein coding gene Chr1:38253345-38393133 (+)
CBA/J MGP_CBAJ_G0015706
protein coding gene Chr1:41442947-41583880 (+)
DBA/2J MGP_DBA2J_G0015807
protein coding gene Chr1:36868381-36994725 (+)
FVB/NJ MGP_FVBNJ_G0015809
protein coding gene Chr1:36403770-36538619 (+)
LP/J MGP_LPJ_G0015877
protein coding gene Chr1:39006740-39138980 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015829
protein coding gene Chr1:43485192-43612478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016401
protein coding gene Chr1:38213367-38346724 (+)
PWK/PhJ MGP_PWKPhJ_G0015098
protein coding gene Chr1:36688055-36820319 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014880
protein coding gene Chr1:38148728-38289974 (+)
WSB/EiJ MGP_WSBEiJ_G0015377
protein coding gene Chr1:38173576-38303634 (+)



Homology
more
  • Human Ortholog
    MAP4K4, mitogen-activated protein kinase kinase kinase kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP4K4, mitogen-activated protein kinase kinase kinase kinase 4
  • Synonyms
    FLH21957, HEL-S-31, HGK, MEKKK4, NIK
  • Links
    NCBI Gene ID: 9448
    neXtProt AC: NX_O95819
    UniProt: O95819

  • Chr Location
    2q11.2; chr2:101696850-101894690 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human MAP4K4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026074 Ensembl Gene Model | MGI Sequence Detail 125398 C57BL/6J ±  kb
    transcript ENSMUST00000163854 Ensembl | MGI Sequence Detail 5782 Not Applicable  
    polypeptide ENSMUSP00000126961 Ensembl | MGI Sequence Detail 1288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-39589, MGI:109590, MGI:1915370, MGI:2138498, MGI:2138507, MGI:2138541
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:39300 Su YC, et al., NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 1997 Mar 17;16(6):1279-90
    • Latest
      J:336925 Huang H, et al., MAP4K4 is involved in the neuronal development of retinal photoreceptors. Exp Eye Res. 2023 Jun 7;233:109524

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory