About   Help   FAQ
Cops3 Gene Detail
Summary
  • Symbol
    Cops3
  • Name
    COP9 signalosome subunit 3
  • Synonyms
    COP9 complex S3, Csn3, Sgn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349409
    NCBI Gene: 26572
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:59708621-59730664 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.80 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349409
 protein coding gene Chr11:59708621-59739080 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018407
 protein coding gene Chr11:59668020-59690775 (-)
A/J MGP_AJ_G0018376
 protein coding gene Chr11:57394464-57416971 (-)
AKR/J MGP_AKRJ_G0018346
 protein coding gene Chr11:59316525-59338407 (-)
BALB/cJ MGP_BALBcJ_G0018347
 protein coding gene Chr11:57742255-57765134 (-)
C3H/HeJ MGP_C3HHeJ_G0018160
 protein coding gene Chr11:59182717-59209868 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018799
 protein coding gene Chr11:61561478-61585262 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016445
 protein coding gene Chr11:54639786-54663490 (-)
CAST/EiJ MGP_CASTEiJ_G0017717
 protein coding gene Chr11:59324922-59346649 (-)
CBA/J MGP_CBAJ_G0018134
 protein coding gene Chr11:64255990-64279126 (-)
DBA/2J MGP_DBA2J_G0018243
 protein coding gene Chr11:57057682-57080094 (-)
FVB/NJ MGP_FVBNJ_G0018234
 protein coding gene Chr11:56715745-56737788 (-)
LP/J MGP_LPJ_G0018316
 protein coding gene Chr11:60267174-60293034 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018258
 protein coding gene Chr11:65347296-65369866 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018840
 protein coding gene Chr11:59341396-59366531 (-)
PWK/PhJ MGP_PWKPhJ_G0017488
 protein coding gene Chr11:57655363-57677354 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017280
 protein coding gene Chr11:59135131-59156838 (-)
WSB/EiJ MGP_WSBEiJ_G0017768
 protein coding gene Chr11:59019253-59041062 (-)



Homology
more
  • Human Ortholog
    COPS3, COP9 signalosome subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPS3, COP9 signalosome subunit 3
  • Synonyms
    CSN3, SGN3
  • Links
    NCBI Gene ID: 8533
    neXtProt AC: NX_Q9UNS2
    UniProt: Q9UNS2

  • Chr Location
    17p11.2; chr17:17246616-17281273 (-)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality with defects in developmental patterning and failure of the inner cell mass to proliferate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    46
  • cDNA Data
    178
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019373 Ensembl Gene Model | MGI Sequence Detail 22044 C57BL/6J ±  kb
    transcript ENSMUST00000019517 Ensembl | MGI Sequence Detail 1646 Not Applicable  
    polypeptide ENSMUSP00000019517 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005740 COP9 signalosome complex subunit 3
      (term hierarchy)
    • InterPro Domains
      IPR050756 COP9 signalosome complex subunit 3
      IPR048621 COP9 signalosome complex subunit 3, C-terminal helix
      IPR000717 Proteasome component (PCI) domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      O88543 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 179
      cDNA 179

      Microarray probesets 5
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Diseases 3
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:317457 Lin H, et al., IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion. Nat Commun. 2021 Apr 28;12(1):2461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory