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Racgap1 Gene Detail
Summary
  • Symbol
    Racgap1
  • Name
    Rac GTPase-activating protein 1
  • Synonyms
    Band25, gtl11, GTPase, MgcRacGAP, mKIAA1478
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349423
    NCBI Gene: 26934
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99518377-99549504 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    861 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349423
 protein coding gene Chr15:99518377-99549537 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022337
 protein coding gene Chr15:101480843-101517711 (-)
A/J MGP_AJ_G0022295
 protein coding gene Chr15:97433945-97465935 (-)
AKR/J MGP_AKRJ_G0022271
 protein coding gene Chr15:100433332-100466589 (-)
BALB/cJ MGP_BALBcJ_G0022301
 protein coding gene Chr15:97618772-97650337 (-)
C3H/HeJ MGP_C3HHeJ_G0022069
 protein coding gene Chr15:100499374-100530868 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022746
 protein coding gene Chr15:105264962-105301664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020272
 protein coding gene Chr15:93329070-93359589 (-)
CAST/EiJ MGP_CASTEiJ_G0021593
 protein coding gene Chr15:101366142-101402803 (-)
CBA/J MGP_CBAJ_G0022038
 protein coding gene Chr15:108835985-108891636 (-)
DBA/2J MGP_DBA2J_G0022165
 protein coding gene Chr15:96870625-96902146 (-)
FVB/NJ MGP_FVBNJ_G0022145
 protein coding gene Chr15:95860457-95891490 (-)
LP/J MGP_LPJ_G0022236
 protein coding gene Chr15:101627972-101662587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022165
 protein coding gene Chr15:112743812-112779556 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022761
 protein coding gene Chr15:100543705-100576525 (-)
PWK/PhJ MGP_PWKPhJ_G0021332
 protein coding gene Chr15:97012377-97044843 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021167
 protein coding gene Chr15:100391720-100425923 (-)
WSB/EiJ MGP_WSBEiJ_G0021644
 protein coding gene Chr15:101063472-101096628 (-)



Homology
more
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
  • Synonyms
    CDAN3B, CYK4, HsCYK-4, ID-GAP, MgcRacGAP
  • Links
    NCBI Gene ID: 29127
    neXtProt AC: NX_Q9H0H5
    UniProt: Q9H0H5

  • Chr Location
    12q13.12; chr12:49976923-50033440 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RACGAP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene-trapped allele exhibit pre-implantation lethality associated with the formation of multinucleated blastomeres and failure to complete cytokinesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    73
  • cDNA Data
    159
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26934 NCBI Gene Model | MGI Sequence Detail 31128 C57BL/6J ±  kb
    transcript NM_012025 RefSeq | MGI Sequence Detail 3032 C57BL/6  
    polypeptide Q9WVM1 UniProt | EBI | MGI Sequence Detail 628 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013663 Rac GTPase-activating protein 1
      (term hierarchy)
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000198 Rho GTPase-activating protein domain
      IPR008936 Rho GTPase activation protein
    • GlyGen
      Q9WVM1 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 162
      cDNA 160
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145962, MGI:2145986
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 31
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory