Mprip MGI Mouse Gene Detail - MGI:1349438 - myosin phosphatase Rho interacting protein

Symbol

Mprip
Name

myosin phosphatase Rho interacting protein
Synonyms

Gm34094, MGC:67316, mKIAA0864, p116 Rho interacting protein, p116Rip, Rhoip3, RIP3

Feature Type

protein coding gene
IDs

MGI:1349438
NCBI Gene: 26936
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:59552973-59671686 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.76 cM
Mapping Data

5 experiments

SNPs within 2kb

2350 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349438	protein coding gene	Chr11:59552131-59671686 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018404	protein coding gene	Chr11:59509667-59631152 (+)
A/J	MGP_AJ_G0018373	protein coding gene	Chr11:57233611-57356674 (+)
AKR/J	MGP_AKRJ_G0018343	protein coding gene	Chr11:59158542-59278373 (+)
BALB/cJ	MGP_BALBcJ_G0018344	protein coding gene	Chr11:57585169-57705378 (+)
C3H/HeJ	MGP_C3HHeJ_G0018157	protein coding gene	Chr11:59023748-59145635 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018796	protein coding gene	Chr11:61397575-61523924 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016442	protein coding gene	Chr11:54479193-54600632 (+)
CAST/EiJ	MGP_CASTEiJ_G0017714	protein coding gene	Chr11:59165885-59287924 (+)
CBA/J	MGP_CBAJ_G0018131	protein coding gene	Chr11:64078530-64208024 (+)
DBA/2J	MGP_DBA2J_G0018240	protein coding gene	Chr11:56899834-57020330 (+)
FVB/NJ	MGP_FVBNJ_G0018231	protein coding gene	Chr11:56555542-56678900 (+)
LP/J	MGP_LPJ_G0018313	protein coding gene	Chr11:60109133-60229711 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018255	protein coding gene	Chr11:65189127-65310430 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018837	protein coding gene	Chr11:59179305-59303085 (+)
PWK/PhJ	MGP_PWKPhJ_G0017485	protein coding gene	Chr11:57495072-57615653 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017277	protein coding gene	Chr11:58974497-59097012 (+)
WSB/EiJ	MGP_WSBEiJ_G0017765	protein coding gene	Chr11:58856641-58982289 (+)

Human Ortholog

MPRIP, myosin phosphatase Rho interacting protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPRIP, myosin phosphatase Rho interacting protein
Synonyms

M-RIP, MRIP, p116Rip, RHOIP3, RIP3
Links

HGNC:30321

NCBI Gene ID: 23164

neXtProt AC: NX_Q6WCQ1

UniProt: Q6WCQ1
Chr Location

17p11.2; chr17:17042457-17217679 (+) GRCh38

MGI Vertebrate Homology

Mprip stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MPRIP
Gene Tree

Mprip

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Mprip
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

6
cDNA Data

300
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mprip

ZFIN mprip

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All Sequences

121
RefSeq

49
UniProt

7
CCDS

CCDS24774.1, CCDS24775.1

Ensembl

ENSMUSG00000005417 (Evidence)
NCBI Gene

26936

			Length	Strain/Species	Flank
genomic	26936	NCBI Gene Model \| MGI Sequence Detail	118714	C57BL/6J	± kb
transcript	NM_001368931	RefSeq \| MGI Sequence Detail	12859	C57BL/6
polypeptide	P97434	UniProt \| EBI \| MGI Sequence Detail	1024	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010549 myosin phosphatase Rho-interacting protein

(term hierarchy)
InterPro Domains

IPR052223 Actin Cytoskeleton Regulatory

IPR039597 Myosin phosphatase-RhoA interacting protein, PH domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain
GlyGen

P97434 1 site, 1 O-linked glycan (1 site)

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All nucleic 304

cDNA 304

Microarray probesets 7

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MGI:2144022, MGI:2144250, MGI:2144618, MGI:5593253

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mprip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101857	Chr11:59553297-59553369 (+)	360 bp
Tssr101858	Chr11:59553498-59553521 (+)	537 bp
Tssr101859	Chr11:59553525-59553585 (+)	582 bp
Tssr101860	Chr11:59597176-59597215 (+)	44,223 bp
Tssr101861	Chr11:59631084-59631104 (+)	78,121 bp
Tssr101862	Chr11:59640985-59641013 (+)	88,026 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24