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Mecr Gene Detail
Summary
  • Symbol
    Mecr
  • Name
    mitochondrial trans-2-enoyl-CoA reductase
  • Synonyms
    Nrbf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349441
    NCBI Gene: 26922
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131570781-131595097 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 64.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    535 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349441
 protein coding gene Chr4:131570755-131595097 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028858
 protein coding gene Chr4:133949455-133980161 (+)
A/J MGP_AJ_G0028817
 protein coding gene Chr4:128387978-128412105 (+)
AKR/J MGP_AKRJ_G0028770
 protein coding gene Chr4:131981422-132010037 (+)
BALB/cJ MGP_BALBcJ_G0028840
 protein coding gene Chr4:129002600-129027172 (+)
C3H/HeJ MGP_C3HHeJ_G0028554
 protein coding gene Chr4:132236157-132261209 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029282
 protein coding gene Chr4:138768274-138794742 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026554
 protein coding gene Chr4:121482212-121508439 (+)
CAST/EiJ MGP_CASTEiJ_G0027987
 protein coding gene Chr4:130298935-130327114 (+)
CBA/J MGP_CBAJ_G0028520
 protein coding gene Chr4:142312153-142336149 (+)
DBA/2J MGP_DBA2J_G0028669
 protein coding gene Chr4:128812407-128837148 (+)
FVB/NJ MGP_FVBNJ_G0028636
 protein coding gene Chr4:127660184-127688581 (+)
LP/J MGP_LPJ_G0028770
 protein coding gene Chr4:134106104-134137354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028662
 protein coding gene Chr4:146957109-146982930 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029320
 protein coding gene Chr4:132376067-132402297 (+)
PWK/PhJ MGP_PWKPhJ_G0027708
 protein coding gene Chr4:125481578-125506773 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027534
 protein coding gene Chr4:128260691-128291407 (+)
WSB/EiJ MGP_WSBEiJ_G0028067
 protein coding gene Chr4:132552768-132582804 (+)



Homology
more
  • Human Ortholog
    MECR, mitochondrial trans-2-enoyl-CoA reductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MECR, mitochondrial trans-2-enoyl-CoA reductase
  • Synonyms
    CGI-63, DYTOABG, ETR1, FASN2B, NRBF1, OPA16
  • Links
    NCBI Gene ID: 51102
    neXtProt AC: NX_Q9BV79
    UniProt: Q9BV79

  • Chr Location
    1p35.3
Human Diseases
more
  • Diseases
    2 with human MECR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutations in this gene lead to embryonic lethality due to pleiotropic effects including abnormalities in fetal placental and cardiovascular development and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    1
  • cDNA Data
    57
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028910 Ensembl Gene Model | MGI Sequence Detail 24317 C57BL/6J ±  kb
    transcript ENSMUST00000030742 Ensembl | MGI Sequence Detail 1337 Not Applicable  
    polypeptide ENSMUSP00000030742 Ensembl | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140207
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:50854 Masuda N, et al., Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Gene. 1998 Oct 23;221(2):225-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory