Gprin1 MGI Mouse Gene Detail - MGI:1349455 - G protein-regulated inducer of neurite outgrowth 1

Symbol

Gprin1
Name

G protein-regulated inducer of neurite outgrowth 1
Synonyms

GRIN1, Z16

Feature Type

protein coding gene
IDs

MGI:1349455
NCBI Gene: 26913
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:54884484-54897486 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.18 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

381 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349455	protein coding gene	Chr13:54884484-54897687 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020578	protein coding gene	Chr13:54149832-54174716 (-)
A/J	MGP_AJ_G0020532	protein coding gene	Chr13:52162763-52176000 (-)
AKR/J	MGP_AKRJ_G0020510	protein coding gene	Chr13:53704173-53719439 (-)
BALB/cJ	MGP_BALBcJ_G0020528	protein coding gene	Chr13:52401613-52415135 (-)
C3H/HeJ	MGP_C3HHeJ_G0020327	protein coding gene	Chr13:53523562-53536148 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020962	protein coding gene	Chr13:55815380-55831219 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018544	protein coding gene	Chr13:50159088-50172212 (-)
CAST/EiJ	MGP_CASTEiJ_G0019841	protein coding gene	Chr13:53608250-53622881 (-)
CBA/J	MGP_CBAJ_G0020287	protein coding gene	Chr13:57931961-57952390 (-)
DBA/2J	MGP_DBA2J_G0020410	protein coding gene	Chr13:51730420-51744228 (-)
FVB/NJ	MGP_FVBNJ_G0020389	protein coding gene	Chr13:51183390-51196145 (-)
LP/J	MGP_LPJ_G0020486	protein coding gene	Chr13:54426717-54442088 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020418	protein coding gene	Chr13:57439887-57455469 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021005	protein coding gene	Chr13:53298290-53308917 (-)
PWK/PhJ	MGP_PWKPhJ_G0019597	protein coding gene	Chr13:51723692-51738360 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019424	protein coding gene	Chr13:52214553-52231213 (-)
WSB/EiJ	MGP_WSBEiJ_G0019903	protein coding gene	Chr13:53629550-53645410 (-)

Human Ortholog

GPRIN1, G protein regulated inducer of neurite outgrowth 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPRIN1, G protein regulated inducer of neurite outgrowth 1
Synonyms

GRIN1
Links

HGNC:24835

NCBI Gene ID: 114787

neXtProt AC: NX_Q7Z2K8

UniProt: Q7Z2K8
Chr Location

5q35.2; chr5:176595802-176610156 (-) GRCh38

MGI Vertebrate Homology

Gprin1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: GPRIN1
Gene Tree

Gprin1

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

2 involving Gprin1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1126
Tissues

189
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gprin1

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All Sequences

41
RefSeq

4
UniProt

1
CCDS

CCDS26534.1

Ensembl

ENSMUSG00000069227 (Evidence)
NCBI Gene

26913

			Length	Strain/Species	Flank
genomic	26913	NCBI Gene Model \| MGI Sequence Detail	13003	C57BL/6J	± kb
transcript	NM_012014	RefSeq \| MGI Sequence Detail	4147	C57BL/6
polypeptide	Q3UNH4	UniProt \| EBI \| MGI Sequence Detail	932	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008199 G protein-regulated inducer of neurite outgrowth 1

(term hierarchy)
InterPro Domains

IPR026646 G protein-regulated inducer of neurite outgrowth

IPR032745 G protein-regulated inducer of neurite outgrowth, C-terminal
GlyGen

Q3UNH4 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)

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All nucleic 15

cDNA 15

Microarray probesets 7

Summaries

All 30

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gprin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122641	Chr13:54897721-54897733 (-)	-241 bp
Tssr122640	Chr13:54897662-54897706 (-)	-198 bp
Tssr122639	Chr13:54897440-54897510 (-)	11 bp
Tssr122638	Chr13:54897426-54897438 (-)	54 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24