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Ecsit Gene Detail
Summary
  • Symbol
    Ecsit
  • Name
    ECSIT signalling integrator
  • Synonyms
    Sitpec
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349469
    NCBI Gene: 26940
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21983542-21996734 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 8.23 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349469
 protein coding gene Chr9:21982731-21997648 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034476
 protein coding gene Chr9:19359131-19373526 (-)
A/J MGP_AJ_G0034454
 protein coding gene Chr9:18976111-18989915 (-)
AKR/J MGP_AKRJ_G0034380
 protein coding gene Chr9:19341907-19355036 (-)
BALB/cJ MGP_BALBcJ_G0034445
 protein coding gene Chr9:18858117-18871423 (-)
C3H/HeJ MGP_C3HHeJ_G0034157
 protein coding gene Chr9:19650847-19666444 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034966
 protein coding gene Chr9:20130434-20144617 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031896
 protein coding gene Chr9:18077031-18090112 (-)
CAST/EiJ MGP_CASTEiJ_G0033480
 protein coding gene Chr9:19486274-19501634 (-)
CBA/J MGP_CBAJ_G0034130
 protein coding gene Chr9:20908216-20926863 (-)
DBA/2J MGP_DBA2J_G0034288
 protein coding gene Chr9:18940604-18953944 (-)
FVB/NJ MGP_FVBNJ_G0034231
 protein coding gene Chr9:18492242-18505545 (-)
LP/J MGP_LPJ_G0034374
 protein coding gene Chr9:19517068-19532052 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034275
 protein coding gene Chr9:22455828-22468781 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034986
 protein coding gene Chr9:19310183-19323359 (-)
PWK/PhJ MGP_PWKPhJ_G0033185
 protein coding gene Chr9:18947775-18961208 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033019
 protein coding gene Chr9:19342452-19355575 (-)
WSB/EiJ MGP_WSBEiJ_G0033595
 protein coding gene Chr9:19049363-19064048 (-)



Homology
more
  • Human Ortholog
    ECSIT, ECSIT signaling integrator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECSIT, ECSIT signaling integrator
  • Synonyms
    SITPEC
  • Links
    NCBI Gene ID: 51295
    neXtProt AC: NX_Q9BQ95
    UniProt: Q9BQ95

  • Chr Location
    19p13.2; chr19:11505929-11529172 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die around the stage of gastrulation showing abnormal epiblast patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    27
  • cDNA Data
    36
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066839 Ensembl Gene Model | MGI Sequence Detail 13193 C57BL/6J ±  kb
    transcript ENSMUST00000179422 Ensembl | MGI Sequence Detail 1462 Not Applicable  
    polypeptide ENSMUSP00000137424 Ensembl | MGI Sequence Detail 435 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:57233 Kopp E, et al., ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 1999 Aug 15;13(16):2059-71
    • Latest
      J:346991 Lin C, et al., Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration. Nat Commun. 2022 Nov 11;13(1):6869
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory