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Trpc7 Gene Detail
Summary
  • Symbol
    Trpc7
  • Name
    transient receptor potential cation channel, subfamily C, member 7
  • Synonyms
    TRP7, Trrp8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349470
    NCBI Gene: 26946
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56920911-57043778 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.27 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349470
 protein coding gene Chr13:56920911-57043806 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020624
 protein coding gene Chr13:56343255-56470445 (-)
A/J MGP_AJ_G0020578
 protein coding gene Chr13:54238703-54361562 (-)
AKR/J MGP_AKRJ_G0020556
 protein coding gene Chr13:55837594-55961078 (-)
BALB/cJ MGP_BALBcJ_G0020574
 protein coding gene Chr13:54477039-54601167 (-)
C3H/HeJ MGP_C3HHeJ_G0020373
 protein coding gene Chr13:55658283-55783369 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021008
 protein coding gene Chr13:58039977-58172326 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018590
 protein coding gene Chr13:52188411-52309402 (-)
CAST/EiJ MGP_CASTEiJ_G0019887
 protein coding gene Chr13:55784501-55908500 (-)
CBA/J MGP_CBAJ_G0020333
 protein coding gene Chr13:60261342-60390867 (-)
DBA/2J MGP_DBA2J_G0020456
 protein coding gene Chr13:53786027-53908494 (-)
FVB/NJ MGP_FVBNJ_G0020435
 protein coding gene Chr13:53263020-53393878 (-)
LP/J MGP_LPJ_G0020532
 protein coding gene Chr13:56589179-56718765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020464
 protein coding gene Chr13:59654346-59793327 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021051
 protein coding gene Chr13:55443559-55575201 (-)
PWK/PhJ MGP_PWKPhJ_G0019643
 protein coding gene Chr13:53834947-53959804 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019470
 protein coding gene Chr13:54389195-54514108 (-)
WSB/EiJ MGP_WSBEiJ_G0019949
 protein coding gene Chr13:55812980-55939236 (-)



Homology
more
  • Human Ortholog
    TRPC7, transient receptor potential cation channel subfamily C member 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC7, transient receptor potential cation channel subfamily C member 7
  • Synonyms
    TRP7
  • Links
    NCBI Gene ID: 57113
    neXtProt AC: NX_Q9HCX4
    UniProt: Q9HCX4

  • Chr Location
    5q31.1; chr5:136212745-136365545 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRPC7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal eye physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    68
  • cDNA Data
    7
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26946 NCBI Gene Model | MGI Sequence Detail 122868 C57BL/6J ±  kb
    transcript NM_001302373 RefSeq | MGI Sequence Detail 3674 C57BL/6  
    polypeptide Q9WVC5 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000001080 short transient receptor potential cation channel TRPC7
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR005821 Ion transport domain
      IPR013555 Transient receptor ion channel domain
      IPR002153 Transient receptor potential channel, canonical
      IPR005463 Transient receptor potential channel, canonical 7
    • GlyGen
      Q9WVC5 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 7
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:349094 Lin Y, et al., TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer. Front Pharmacol. 2024;15:1392328
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory