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Ppp2r5c Gene Detail
Summary
  • Symbol
    Ppp2r5c
  • Name
    protein phosphatase 2, regulatory subunit B', gamma
  • Synonyms
    2610043M05Rik, 2700063L20Rik, B56/PP2A gamma, Band 8A, D12Bwg0916e, mKIAA0044
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349475
    NCBI Gene: 26931
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:110413554-110549496 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.56 cM, cytoband F2
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4243 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349475
 protein coding gene Chr12:110413532-110549509 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020117
 protein coding gene Chr12:112747517-112889642 (+)
A/J MGP_AJ_G0020071
 protein coding gene Chr12:108411256-108508216 (+)
AKR/J MGP_AKRJ_G0020047
 protein coding gene Chr12:111550200-111687528 (+)
BALB/cJ MGP_BALBcJ_G0020057
 protein coding gene Chr12:108856138-108993163 (+)
C3H/HeJ MGP_C3HHeJ_G0019859
 protein coding gene Chr12:111999242-112138076 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020502
 protein coding gene Chr12:116185587-116335844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018114
 protein coding gene Chr12:104874274-105023481 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0019826
 protein coding gene Chr12:120727570-120880465 (+)
DBA/2J MGP_DBA2J_G0019943
 protein coding gene Chr12:107925916-108057800 (+)
FVB/NJ MGP_FVBNJ_G0019928
 protein coding gene Chr12:106683393-106853989 (+)
LP/J MGP_LPJ_G0020018
 protein coding gene Chr12:112578608-112725099 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019966
 protein coding gene Chr12:123858916-124009478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020531
 protein coding gene Chr12:111077292-111176286 (+)
PWK/PhJ MGP_PWKPhJ_G0019160
 protein coding gene Chr12:102540667-102679449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018964
 protein coding gene Chr12:105239832-105340047 (+)
WSB/EiJ MGP_WSBEiJ_G0019458
 protein coding gene Chr12:111947580-112084722 (+)



Homology
more
  • Human Ortholog
    PPP2R5C, protein phosphatase 2 regulatory subunit B'gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R5C, protein phosphatase 2 regulatory subunit B'gamma
  • Synonyms
    B56G, B56gamma, PR61G
  • Links
    NCBI Gene ID: 5527
    neXtProt AC: NX_Q13362
    UniProt: Q13362

  • Chr Location
    14q32.31; chr14:101760573-101927992 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele show partial neonatal lethality, hypoactivity, and abnormal ventricular septum formation associated with increased fetal cardiomyocyte apoptosis. Surviving homozygotes develop obesity and show an abnormal gait, decreased grip strength, and impaired balance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    95
  • cDNA Data
    24
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017843 Ensembl Gene Model | MGI Sequence Detail 135943 C57BL/6J ±  kb
    transcript ENSMUST00000084985 Ensembl | MGI Sequence Detail 1847 Not Applicable  
    polypeptide ENSMUSP00000082053 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013145 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR002554 Protein phosphatase 2A, regulatory B subunit, B56
    • GlyGen
      Q60996 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 28
      Primer pair 6

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-34036, MGI:106344, MGI:1917494, MGI:1922861, MGI:2144759, MGI:2145038, MGI:3034420
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:51733 Francia G, et al., Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression. Cancer Res. 1996 Sep 1;56(17):3855-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory