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Zw10 Gene Detail
Summary
  • Symbol
    Zw10
  • Name
    zw10 kinetochore protein
  • Synonyms
    6330566F14Rik, MmZw10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349478
    NCBI Gene: 26951
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:48966913-48990075 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.58 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    757 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349478
 protein coding gene Chr9:48966880-48990075 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034768
 protein coding gene Chr9:47870123-47897952 (+)
A/J MGP_AJ_G0034749
 protein coding gene Chr9:46441665-46466619 (+)
AKR/J MGP_AKRJ_G0034677
 protein coding gene Chr9:47411907-47435103 (+)
BALB/cJ MGP_BALBcJ_G0034741
 protein coding gene Chr9:46162829-46185490 (+)
C3H/HeJ MGP_C3HHeJ_G0034451
 protein coding gene Chr9:47864297-47890771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035261
 protein coding gene Chr9:49226894-49255218 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032174
 protein coding gene Chr9:45928128-45951896 (+)
CAST/EiJ MGP_CASTEiJ_G0033773
 protein coding gene Chr9:47812272-47838497 (+)
CBA/J MGP_CBAJ_G0034423
 protein coding gene Chr9:50975732-51004237 (+)
DBA/2J MGP_DBA2J_G0034582
 protein coding gene Chr9:46296526-46318764 (+)
FVB/NJ MGP_FVBNJ_G0034523
 protein coding gene Chr9:45544797-45568030 (+)
LP/J MGP_LPJ_G0034663
 protein coding gene Chr9:48237815-48261746 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034567
 protein coding gene Chr9:52658592-52682826 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035282
 protein coding gene Chr9:47352850-47382565 (+)
PWK/PhJ MGP_PWKPhJ_G0033478
 protein coding gene Chr9:46263350-46286997 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033313
 protein coding gene Chr9:47665132-47693159 (+)
WSB/EiJ MGP_WSBEiJ_G0033886
 protein coding gene Chr9:47385774-47412173 (+)



Homology
more
  • Human Ortholog
    ZW10, zw10 kinetochore protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZW10, zw10 kinetochore protein
  • Synonyms
    HZW10, KNTC1AP
  • Links
    NCBI Gene ID: 9183
    neXtProt AC: NX_O43264
    UniProt: O43264

  • Chr Location
    11q23.2; chr11:113733187-113773735 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    67
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032264 Ensembl Gene Model | MGI Sequence Detail 23163 C57BL/6J ±  kb
transcript ENSMUST00000034803 Ensembl | MGI Sequence Detail 2863 Not Applicable  
polypeptide ENSMUSP00000034803 Ensembl | MGI Sequence Detail 779 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000018235 centromere/kinetochore protein zw10
    (term hierarchy)
  • InterPro Domains
    IPR048343 Centromere/kinetochore protein zw10, C-terminal domain
    IPR048344 Centromere/kinetochore protein zw10, middle domain
    IPR009361 Centromere/kinetochore protein zw10, N-terminal
    IPR046362 Zw10/DSL1, C-terminal
  • GlyGen
    O54692 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 67
    cDNA 67

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923439
References
more
  • Summaries
    All 28
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:51740 Starr DA, et al., Conservation of the centromere/kinetochore protein ZW10. J Cell Biol. 1997 Sep 22;138(6):1289-301
  • Latest
    J:301696 Park Y, et al., Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes. Histochem Cell Biol. 2019 Sep;152(3):207-215
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory