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Chst4 Gene Detail
Summary
  • Symbol
    Chst4
  • Name
    carbohydrate sulfotransferase 4
  • Synonyms
    GST-3, HEC-GlcNAc6ST, high endothelial cell GlcNAC-6-sulphotransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349479
    NCBI Gene: 26887
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110755776-110766033 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.38 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349479
 protein coding gene Chr8:110755776-110766372 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034118
 protein coding gene Chr8:112653039-112668707 (-)
A/J MGP_AJ_G0034097
 protein coding gene Chr8:108089901-108101920 (-)
AKR/J MGP_AKRJ_G0034024
 protein coding gene Chr8:111261678-111277443 (-)
BALB/cJ MGP_BALBcJ_G0034091
 protein coding gene Chr8:108295053-108305308 (-)
C3H/HeJ MGP_C3HHeJ_G0033802
 protein coding gene Chr8:111966121-111977590 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034611
 protein coding gene Chr8:116638018-116651484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031553
 protein coding gene Chr8:101120671-101130830 (-)
CAST/EiJ MGP_CASTEiJ_G0033129
 protein coding gene Chr8:111576769-111588082 (-)
CBA/J MGP_CBAJ_G0033776
 protein coding gene Chr8:120546698-120564426 (-)
DBA/2J MGP_DBA2J_G0033931
 protein coding gene Chr8:107414801-107425943 (-)
FVB/NJ MGP_FVBNJ_G0033875
 protein coding gene Chr8:106360959-106371022 (-)
LP/J MGP_LPJ_G0034021
 protein coding gene Chr8:112831508-112843817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033921
 protein coding gene Chr8:123555561-123565904 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034630
 protein coding gene Chr8:111216904-111230633 (-)
PWK/PhJ MGP_PWKPhJ_G0032832
 protein coding gene Chr8:106979291-106989391 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032671
 protein coding gene Chr8:109906876-109922845 (-)
WSB/EiJ MGP_WSBEiJ_G0033245
 protein coding gene Chr8:111904946-111916280 (-)



Homology
more
  • Human Ortholog
    CHST4, carbohydrate sulfotransferase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHST4, carbohydrate sulfotransferase 4
  • Synonyms
    GlcNAc6ST2, GST3, HECGLCNAC6ST, LSST
  • Links
    NCBI Gene ID: 10164
    neXtProt AC: NX_Q8NCG5
    UniProt: Q8NCG5

  • Chr Location
    16q22.2; chr16:71525233-71538748 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene do not accumulate lymphocytes in peripheral lymph nodes to as great an extent as normal. The animals are phenotypically normal otherwise.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    105
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26887 NCBI Gene Model | MGI Sequence Detail 10258 C57BL/6J ±  kb
    transcript NM_011998 RefSeq | MGI Sequence Detail 1975 C57BL/6  
    polypeptide Q9R1I1 UniProt | EBI | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:57381 Hiraoka N, et al., A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34. Immunity. 1999 Jul;11(1):79-89
    • Latest
      J:341365 Abo H, et al., N-acetylglucosamine-6-O sulfation on intestinal mucins prevents obesity and intestinal inflammation by regulating gut microbiota. JCI Insight. 2023 Aug 22;8(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory