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Islr Gene Detail
Summary
  • Symbol
    Islr
  • Name
    immunoglobulin superfamily containing leucine-rich repeat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349645
    NCBI Gene: 26968
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58063547-58066563 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349645
 protein coding gene Chr9:58063547-58111589 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034885
 protein coding gene Chr9:57426022-57428978 (-)
A/J MGP_AJ_G0034866
 protein coding gene Chr9:55563043-55565999 (-)
AKR/J MGP_AKRJ_G0034795
 protein coding gene Chr9:56857119-56860083 (-)
BALB/cJ MGP_BALBcJ_G0034858
 protein coding gene Chr9:55337085-55340041 (-)
C3H/HeJ MGP_C3HHeJ_G0034568
 protein coding gene Chr9:57328328-57331284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035377
 protein coding gene Chr9:59015279-59018235 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032288
 protein coding gene Chr9:54849324-54852252 (-)
CAST/EiJ MGP_CASTEiJ_G0033889
 protein coding gene Chr9:57423793-57426753 (-)
CBA/J MGP_CBAJ_G0034539
 protein coding gene Chr9:61090010-61092966 (-)
DBA/2J MGP_DBA2J_G0034698
 protein coding gene Chr9:55420839-55423795 (-)
FVB/NJ MGP_FVBNJ_G0034640
 protein coding gene Chr9:54654618-54657582 (-)
LP/J MGP_LPJ_G0034781
 protein coding gene Chr9:57710157-57713113 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034683
 protein coding gene Chr9:62552261-62555225 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035399
 protein coding gene Chr9:56868859-56871819 (-)
PWK/PhJ MGP_PWKPhJ_G0033594
 protein coding gene Chr9:55463879-55466858 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033428
 protein coding gene Chr9:57138622-57141597 (-)
WSB/EiJ MGP_WSBEiJ_G0034002
 protein coding gene Chr9:56805763-56808734 (-)



Homology
more
  • Human Ortholog
    ISLR, immunoglobulin superfamily containing leucine rich repeat
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISLR, immunoglobulin superfamily containing leucine rich repeat
  • Synonyms
    HsT17563, Meflin
  • Links
    NCBI Gene ID: 3671
    neXtProt AC: NX_O14498
    UniProt: O14498

  • Chr Location
    15q24.1; chr15:74173710-74176872 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene product suppresses differentiation of bone marrow stromal and skeletal stem cells into skeletal lineages. Homozygous knockout leads to growth retardation and longer long bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    52
  • cDNA Data
    83
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26968 NCBI Gene Model | MGI Sequence Detail 3017 C57BL/6J ±  kb
    transcript NM_012043 RefSeq | MGI Sequence Detail 2243 C57BL/6  
    polypeptide Q6GU68 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000032212 immunoglobulin superfamily containing leucine-rich repeat protein
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003598 Immunoglobulin subtype 2
      IPR001611 Leucine-rich repeat
      IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q6GU68 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 83
      Primer pair 1
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143325
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 10
      Gene Ontology 1
      Phenotypes 21
    • Earliest
      J:58085 Nagasawa A, et al., Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression. Genomics. 1999 Oct 1;61(1):37-43
    • Latest
      J:358039 Ando R, et al., Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas. J Pathol. 2024 Jan;262(1):61-75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory