Gimap4 MGI Mouse Gene Detail - MGI:1349656 - GTPase, IMAP family member 4

Symbol

Gimap4
Name

GTPase, IMAP family member 4
Synonyms

E430007K16Rik, Ian1

Feature Type

protein coding gene
IDs

MGI:1349656
NCBI Gene: 107526
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr6:48661483-48668994 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.66 cM
Mapping Data

2 experiments

SNPs within 2kb

289 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349656	protein coding gene	Chr6:48661453-48668996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030706	protein coding gene	Chr6:47640379-47647890 (+)
A/J	MGP_AJ_G0030677	protein coding gene	Chr6:45475382-45482891 (+)
AKR/J	MGP_AKRJ_G0030602	protein coding gene	Chr6:47073376-47080887 (+)
BALB/cJ	MGP_BALBcJ_G0030687	protein coding gene	Chr6:45807429-45814942 (+)
C3H/HeJ	MGP_C3HHeJ_G0030400	protein coding gene	Chr6:47076696-47084219 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031142	protein coding gene	Chr6:48757580-48765091 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028349	protein coding gene	Chr6:43103695-43111871 (+)
CAST/EiJ	MGP_CASTEiJ_G0029804	protein coding gene	Chr6:46804375-46811868 (+)
CBA/J	MGP_CBAJ_G0030375	protein coding gene	Chr6:50781272-50789287 (+)
DBA/2J	MGP_DBA2J_G0030524	protein coding gene	Chr6:45392752-45400263 (+)
FVB/NJ	MGP_FVBNJ_G0030476	protein coding gene	Chr6:45024855-45032366 (+)
LP/J	MGP_LPJ_G0030609	protein coding gene	Chr6:47619917-47627428 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030510	protein coding gene	Chr6:53592685-53600194 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031171	protein coding gene	Chr6:46941094-46948605 (+)
PWK/PhJ	MGP_PWKPhJ_G0029516	protein coding gene	Chr6:44924904-44932408 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029352	protein coding gene	Chr6:46287890-46295378 (+)
WSB/EiJ	MGP_WSBEiJ_G0029881	protein coding gene	Chr6:46940435-46947946 (+)

Human Ortholog

GIMAP4, GTPase, IMAP family member 4

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GIMAP4, GTPase, IMAP family member 4
Synonyms

IAN-1, IAN1, IMAP4, MSTP062
Links

HGNC:21872

NCBI Gene ID: 55303

neXtProt AC: NX_Q9NUV9

UniProt: Q9NUV9
Chr Location

7q36.1; chr7:150567369-150573953 (+) GRCh38

MGI Vertebrate Homology

Gimap4 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: GIMAP4
Gene Tree

Gimap4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a knock-out allele show no detectable alterations in T-cell development, selection and activation; however, mutant T cells exhibit a delay in the execution of programmed cell death induced by intrinsic stimuli downstream of caspase-3 activation and phosphatidylserine exposure.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

62
RefSeq

12
UniProt

5
CCDS

CCDS20110.1, CCDS39481.2, CCDS57421.1, CCDS57422.1, CCDS57423.1

Ensembl

ENSMUSG00000054435 (Evidence)
NCBI Gene

107526

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054435	Ensembl Gene Model \| MGI Sequence Detail	7512	C57BL/6J	± kb
transcript	ENSMUST00000090070	Ensembl \| MGI Sequence Detail	1804	Not Applicable
polypeptide	ENSMUSP00000087524	Ensembl \| MGI Sequence Detail	328	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007978 GTPase IMAP family member 4

(term hierarchy)
InterPro Domains

IPR006703 AIG1-type guanine nucleotide-binding (G) domain

IPR045058 GTPase GIMA/IAN/Toc

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 14

Genomic 2

cDNA 12

Microarray probesets 4

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MGI:2141562

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 3
Earliest

J:58144 Poirier GM, et al., Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker and defines a novel gene family conserved in plants. J Immunol. 1999 Nov 1;163(9):4960-9
Latest

J:267911 Timmermans S, et al., Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. JCI Insight. 2018 Jul 12;3(13)

TSS for Gimap4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56170	Chr6:48661478-48661490 (+)	1 bp
Tssr56171	Chr6:48661504-48661520 (+)	29 bp
Tssr56172	Chr6:48661523-48661532 (+)	45 bp
Tssr56173	Chr6:48662075-48662120 (+)	615 bp
Tssr56174	Chr6:48662436-48662447 (+)	959 bp
Tssr56175	Chr6:48662874-48662910 (+)	1,409 bp
Tssr56176	Chr6:48663523-48663541 (+)	2,049 bp
Tssr56177	Chr6:48664614-48664627 (+)	3,138 bp
Tssr56178	Chr6:48667580-48667592 (+)	6,103 bp
Tssr56179	Chr6:48667613-48667625 (+)	6,136 bp
Tssr56180	Chr6:48667992-48668003 (+)	6,515 bp
Tssr56181	Chr6:48668288-48668316 (+)	6,819 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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