Tob1 MGI Mouse Gene Detail - MGI:1349721

Symbol

Tob1
Name

transducer of ErbB-2.1
Synonyms

Tob, Trob

Feature Type

protein coding gene
IDs

MGI:1349721
NCBI Gene: 22057
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:94102280-94106321 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.90 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

116 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349721	protein coding gene	Chr11:94100668-94106321 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018950	protein coding gene	Chr11:96276516-96283418 (+)
A/J	MGP_AJ_G0018918	protein coding gene	Chr11:92439645-92443638 (+)
AKR/J	MGP_AKRJ_G0018888	protein coding gene	Chr11:95313354-95317347 (+)
BALB/cJ	MGP_BALBcJ_G0018891	protein coding gene	Chr11:92874196-92878336 (+)
C3H/HeJ	MGP_C3HHeJ_G0018705	protein coding gene	Chr11:95392451-95396444 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019343	protein coding gene	Chr11:99281018-99284892 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016974	protein coding gene	Chr11:89934981-89938960 (+)
CAST/EiJ	MGP_CASTEiJ_G0018260	protein coding gene	Chr11:96095456-96099454 (+)
CBA/J	MGP_CBAJ_G0018676	protein coding gene	Chr11:103385516-103389509 (+)
DBA/2J	MGP_DBA2J_G0018784	protein coding gene	Chr11:92014342-92018247 (+)
FVB/NJ	MGP_FVBNJ_G0018773	protein coding gene	Chr11:91425691-91433899 (+)
LP/J	MGP_LPJ_G0018854	protein coding gene	Chr11:96820482-96824464 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018800	protein coding gene	Chr11:103440447-103447204 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019383	protein coding gene	Chr11:95528241-95533356 (+)
PWK/PhJ	MGP_PWKPhJ_G0018030	protein coding gene	Chr11:92938710-92942767 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017820	protein coding gene	Chr11:95198649-95202636 (+)
WSB/EiJ	MGP_WSBEiJ_G0018309	protein coding gene	Chr11:95408384-95412382 (+)

Human Ortholog

TOB1, transducer of ERBB2, 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOB1, transducer of ERBB2, 1
Synonyms

APRO5, APRO6, PIG49, TOB, TROB, TROB1
Links

HGNC:11979

NCBI Gene ID: 10140

neXtProt AC: NX_P50616

UniProt: P50616
Chr Location

17q21.33; chr17:50862223-50867978 (-) GRCh38

MGI Vertebrate Homology

Tob1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TOB1
Gene Tree

Tob1

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

4
Targeted

7
Genomic Mutations

3 involving Tob1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and exhibit increased bone mass due to increased osteoblast proliferation and differentiation.

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All GO Annotations

31
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

25
cDNA Data

54
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TOB1

Xenbase tob1

ZFIN tob1a

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS25250.1

Ensembl

ENSMUSG00000037573 (Evidence)
NCBI Gene

22057

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037573	Ensembl Gene Model \| MGI Sequence Detail	4042	C57BL/6J	± kb
transcript	ENSMUST00000041589	Ensembl \| MGI Sequence Detail	2288	Not Applicable
polypeptide	ENSMUSP00000036039	Ensembl \| MGI Sequence Detail	362	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016525 protein Tob1

(term hierarchy)
InterPro Domains

IPR002087 Anti-proliferative protein

IPR036054 BTG-like domain superfamily

IPR015676 Tob1/2
GlyGen

Q61471 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 59

Genomic 3

cDNA 54

Primer pair 1

Other 1

Microarray probesets 4

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MGI:894690

Summaries

All 59

Developmental Gene Expression 7

Diseases 1

Gene Ontology 7

Phenotypes 26
Earliest

J:41178 Yoshida Y, et al., Cloning and characterization of the mouse tob gene. Gene. 1997 May 20;191(1):109-13
Latest

J:353812 Kitajima Y, et al., Loss of Tob1 promotes muscle regeneration through muscle stem cell expansion. J Cell Sci. 2024 Aug 1;137(15):jcs261886

TSS for Tob1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104182	Chr11:94102257-94102272 (+)	-15 bp
Tssr104183	Chr11:94104643-94104660 (+)	2,372 bp
Tssr104184	Chr11:94104803-94104815 (+)	2,529 bp
Tssr104185	Chr11:94105383-94105417 (+)	3,120 bp
Tssr104186	Chr11:94105632-94105643 (+)	3,358 bp
Tssr104187	Chr11:94105653-94105664 (+)	3,379 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24