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Rcn2 Gene Detail
Summary
  • Symbol
    Rcn2
  • Name
    reticulocalbin 2
  • Synonyms
    taipoxin-associated calcium binding protein 49, TCBP-49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349765
    NCBI Gene: 26611
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:55949129-55966367 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.13 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349765
 protein coding gene Chr9:55949129-55969166 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034846
 protein coding gene Chr9:55176729-55198232 (+)
A/J MGP_AJ_G0034827
 protein coding gene Chr9:53385081-53405411 (+)
AKR/J MGP_AKRJ_G0034756
 protein coding gene Chr9:54622118-54642442 (+)
BALB/cJ MGP_BALBcJ_G0034819
 protein coding gene Chr9:53166799-53192605 (+)
C3H/HeJ MGP_C3HHeJ_G0034529
 protein coding gene Chr9:55082171-55104982 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035338
 protein coding gene Chr9:56729160-56750169 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032249
 protein coding gene Chr9:52739389-52759519 (+)
CAST/EiJ MGP_CASTEiJ_G0033850
 protein coding gene Chr9:55124499-55144726 (+)
CBA/J MGP_CBAJ_G0034500
 protein coding gene Chr9:58672067-58697473 (+)
DBA/2J MGP_DBA2J_G0034659
 protein coding gene Chr9:53274868-53296038 (+)
FVB/NJ MGP_FVBNJ_G0034601
 protein coding gene Chr9:52479820-52500629 (+)
LP/J MGP_LPJ_G0034742
 protein coding gene Chr9:55471172-55491516 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034644
 protein coding gene Chr9:60202222-60223045 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035360
 protein coding gene Chr9:54629332-54651394 (+)
PWK/PhJ MGP_PWKPhJ_G0033555
 protein coding gene Chr9:53279215-53299699 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033389
 protein coding gene Chr9:54912530-54932708 (+)
WSB/EiJ MGP_WSBEiJ_G0033963
 protein coding gene Chr9:54561177-54583522 (+)



Homology
more
  • Human Ortholog
    RCN2, reticulocalbin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RCN2, reticulocalbin 2
  • Synonyms
    E6BP, ERC-55, ERC55, TCBP49
  • Links
    NCBI Gene ID: 5955
    neXtProt AC: NX_Q14257
    UniProt: Q14257

  • Chr Location
    15q24.3; chr15:76931738-76954393 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lowered basal blood pressure and attenuated angiotensin II-induced hypertension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    21
  • cDNA Data
    105
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26611 NCBI Gene Model | MGI Sequence Detail 17239 C57BL/6J ±  kb
    transcript NM_011992 RefSeq | MGI Sequence Detail 2042 C57BL/6  
    polypeptide Q8BP92 UniProt | EBI | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 105

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142924
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:51718 Dodds D, et al., Novel reticular calcium binding protein is purified on taipoxin columns. J Neurochem. 1995 May;64(5):2339-44
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory