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Brd7 Gene Detail
Summary
  • Symbol
    Brd7
  • Name
    bromodomain containing 7
  • Synonyms
    BP75, bromodomain protein 75 kDa, CELTIX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349766
    NCBI Gene: 26992
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:89057667-89088822 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 43.07 cM, cytoband C4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    761 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349766
 protein coding gene Chr8:89056522-89089249 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033919
 protein coding gene Chr8:89410204-89441181 (-)
A/J MGP_AJ_G0033902
 protein coding gene Chr8:85891910-85923077 (-)
AKR/J MGP_AKRJ_G0033828
 protein coding gene Chr8:88417940-88451763 (-)
BALB/cJ MGP_BALBcJ_G0033895
 protein coding gene Chr8:86053211-86084871 (-)
C3H/HeJ MGP_C3HHeJ_G0033605
 protein coding gene Chr8:89018804-89051252 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034415
 protein coding gene Chr8:92778754-92812572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031357
 protein coding gene Chr8:79868794-79899837 (-)
CAST/EiJ MGP_CASTEiJ_G0032936
 protein coding gene Chr8:88455073-88486577 (-)
CBA/J MGP_CBAJ_G0033581
 protein coding gene Chr8:95925099-95956207 (-)
DBA/2J MGP_DBA2J_G0033734
 protein coding gene Chr8:85481228-85512280 (-)
FVB/NJ MGP_FVBNJ_G0033681
 protein coding gene Chr8:84440940-84472561 (-)
LP/J MGP_LPJ_G0033826
 protein coding gene Chr8:89524719-89555821 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033724
 protein coding gene Chr8:98384322-98416477 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034434
 protein coding gene Chr8:88429018-88461428 (-)
PWK/PhJ MGP_PWKPhJ_G0032639
 protein coding gene Chr8:84750958-84782712 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032475
 protein coding gene Chr8:87235692-87267453 (-)
WSB/EiJ MGP_WSBEiJ_G0033047
 protein coding gene Chr8:88872370-88907689 (-)



Homology
more
  • Human Ortholog
    BRD7, bromodomain containing 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRD7, bromodomain containing 7
  • Synonyms
    BP75, CELTIX1, NAG4, SMARCI1
  • Links
    NCBI Gene ID: 29117
    neXtProt AC: NX_Q9NPI1
    UniProt: Q9NPI1

  • Chr Location
    16q12.1; chr16:50313487-50368988 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BRD7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 4 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired cognitive behavior and dendrite morphology in the medial prefrontal cortex as well as male infertility with azoospermia and globozoospermia. Mice homozygous for a different knock-out allele die in utero prior to E16.5, showing fetal growth retardation and altered limb, blood vessel and organ development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    119
  • cDNA Data
    138
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031660 Ensembl Gene Model | MGI Sequence Detail 31156 C57BL/6J ±  kb
    transcript ENSMUST00000249591 Ensembl | MGI Sequence Detail 3625 Not Applicable  
    polypeptide ENSMUSP00000159801 Ensembl | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      cDNA 140
      Primer pair 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 14
      Gene Ontology 23
      Phenotypes 46
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory